SERPINF2 and TGM2

Number of citations of the paper that reports this interaction (PMID 10958788)
5

Data Source:
HPRD (in vitro)

		SERPINF2	TGM2
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	transglutaminase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs		Ocriplasmin	Guanosine-5\'-Diphosphate
Diseases
GWAS		Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		5345	7052
HPRD ID		02029	01825
Ensembl ID		ENSG00000167711	ENSG00000198959
Uniprot IDs		P08697	B4DIT7 F5H6P0 P21980
PDB IDs			1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process	Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus
Tagcloud ?			antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately
Tagcloud (Difference) ?			antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately
Tagcloud (Intersection) ?