PAX2 and MAPK8IP1

Number of citations of the paper that reports this interaction (PMID 11700324)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PAX2	MAPK8IP1
Gene Name		paired box 2	mitogen-activated protein kinase 8 interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Microtubule Organizing Center Protein-DNA Complex Centriolar Satellite Protein Complex	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Protein Binding Transcription Factor Binding Superoxide-generating NADPH Oxidase Activity Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Axonogenesis Mesodermal Cell Fate Specification Aging Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Pancreas Development Response To Nutrient Levels Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Oxidation-reduction Process Mesenchymal To Epithelial Transition Paramesonephric Duct Development Optic Chiasma Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Epidermal Growth Factor Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Formation Mesonephric Duct Development Nephric Duct Formation Ureter Development Ureter Morphogenesis Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Reactive Oxygen Species Metabolic Process Cochlea Development Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627)
Protein-Protein Interactions		11 interactors: BBS1 BBS2 BBS4 BBS7 ID2 MAPK8 MAPK8IP1 PAXIP1 RB1 SFRP2 WT1	25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2
Entrez ID		5076	9479
HPRD ID		01330	05223
Ensembl ID		ENSG00000075891	ENSG00000121653
Uniprot IDs		Q02962	E9PBB9 Q6NUQ9 Q9UQF2
PDB IDs			2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Anatomical Structure Morphogenesis Tissue Development Tube Development Digestive Tract Development Photoreceptor Cell Maintenance Melanosome Transport Digestive System Development Pigment Granule Transport Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Establishment Of Melanosome Localization Cilium Assembly Melanosome Localization Tube Morphogenesis Visual Perception Sensory Perception Of Light Stimulus Cardiovascular System Development Cilium Organization Regulation Of Gene Expression JUN Phosphorylation Cilium Morphogenesis Heart Development Organ Morphogenesis Positive Regulation Of Growth Heart Morphogenesis Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cellular Pigmentation Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Connective Tissue Development Digestive Tract Morphogenesis Leptin-mediated Signaling Pathway Cell Projection Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Developmental Growth Organ Development Negative Regulation Of Appetite Response To Stimulus Negative Regulation Of Gene Expression Establishment Of Organelle Localization Positive Regulation Of Macrophage Differentiation Cellular Response To Leptin Stimulus Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Regulation Of Microtubule-based Movement Pigmentation Cell Differentiation Epithelial Tube Morphogenesis Striatum Development	JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts	advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse
Tagcloud (Difference) ?		agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts	advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse
Tagcloud (Intersection) ?