NEK1 and FEZ1

Number of citations of the paper that reports this interaction (PMID 14690447)
15

Data Source:
HPRD (two hybrid, in vitro)

		NEK1	FEZ1
Gene Name		NIMA-related kinase 1	fasciculation and elongation protein zeta 1 (zygin I)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Nucleus Cytoplasm Centrosome	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Cilium Assembly Cell Division	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways
Drugs
Diseases
GWAS			Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		13 interactors: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A MRE11A PPP2R5A TP53BP1 TSC2 YWHAH ZNF350	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		4750	9638
HPRD ID		06847	09212
Ensembl ID		ENSG00000137601	ENSG00000149557
Uniprot IDs		Q5JXL9 Q96PY6	Q99689
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?		Response To Stimulus Regulation Of Cellular Component Organization Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Nervous System Development Regulation Of Cellular Process DNA Recombination Glucocorticoid Catabolic Process Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Dendrite Morphogenesis DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Generation Of Neurons DNA Modification Neurogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Dendrite Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Lipid Kinase Activity Cellular Response To Hydroxyurea DNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Stem Cell Homeostasis Regulation Of DNA Replication Signal Transduction Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Transport Into Plasma Membrane Raft Cell Projection Organization Double-strand Break Repair System Development Regulation Of Mitotic Recombination Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Plasma Membrane Raft Regulation Of Transcription, DNA-templated Nuclear MRNA Surveillance DNA Repair Chemotaxis Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cell Communication Positive Regulation Of Transcription, DNA-templated Regulation Of Endocytosis Regulation Of RNA Metabolic Process Cullin Deneddylation	Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated
Tagcloud ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?