NEK1 and TSC2

Number of citations of the paper that reports this interaction (PMID 14690447)
15

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NEK1	TSC2
Gene Name		NIMA-related kinase 1	tuberous sclerosis 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Nucleus Cytoplasm Centrosome	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Caveola Membrane Dendrite Growth Cone TSC1-TSC2 Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Phosphatase Binding Protein Homodimerization Activity Protein Heterodimerization Activity 14-3-3 Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Cilium Assembly Cell Division	Response To Hypoxia Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Acute-phase Response Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Heart Development Protein Localization Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Cell Projection Organization Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Ras GTPase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Protein Transport Into Plasma Membrane Raft Innate Immune Response Negative Regulation Of Cell Size Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Protein Homooligomerization Protein Heterooligomerization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulation of Rheb GTPase activity by AMPK mTOR signalling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Inhibition of TSC complex formation by PKB PIP3 activates AKT signaling IRS-mediated signalling mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Energy dependent regulation of mTOR by LKB1-AMPK Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Inhibition of TSC complex formation by PKB Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A MRE11A PPP2R5A TP53BP1 TSC2 YWHAH ZNF350	40 interactors: AKT1 AKT2 AKT3 CALM1 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PPP2CA PRKAA1 PTK2 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SPERT TBC1D7 TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		4750	7249
HPRD ID		06847	01850
Ensembl ID		ENSG00000137601	ENSG00000103197
Uniprot IDs		Q5JXL9 Q96PY6	P49815
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?		Response To Stimulus Regulation Of Cellular Component Organization Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Nervous System Development Regulation Of Cellular Process DNA Recombination Glucocorticoid Catabolic Process Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Dendrite Morphogenesis DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Generation Of Neurons DNA Modification Neurogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Dendrite Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Lipid Kinase Activity Cellular Response To Hydroxyurea DNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Stem Cell Homeostasis Regulation Of DNA Replication Signal Transduction Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Transport Into Plasma Membrane Raft Cell Projection Organization Double-strand Break Repair System Development Regulation Of Mitotic Recombination Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Plasma Membrane Raft Regulation Of Transcription, DNA-templated Nuclear MRNA Surveillance DNA Repair Chemotaxis Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cell Communication Positive Regulation Of Transcription, DNA-templated Regulation Of Endocytosis Regulation Of RNA Metabolic Process Cullin Deneddylation	Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Transport Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Mitochondrion Organization Response To Growth Factor Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Response To Organic Substance Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Apoptotic Process Signal Transduction Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Mitochondrion Organization Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Cellular Response To Insulin Stimulus Response To Stimulus Cellular Response To Peptide Hormone Stimulus
Tagcloud ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin	c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous
Tagcloud (Difference) ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin	c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous
Tagcloud (Intersection) ?