NEK1 and ATRX

Number of citations of the paper that reports this interaction (PMID 14690447)
15

Data Source:
HPRD (two hybrid)

		NEK1	ATRX
Gene Name		NIMA-related kinase 1	alpha thalassemia/mental retardation syndrome X-linked
Image
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Nucleus Cytoplasm Centrosome	Nucleus Nucleoplasm Nuclear Heterochromatin PML Body Telomeric Heterochromatin SWI/SNF Superfamily-type Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding DNA Translocase Activity Methylated Histone Binding Histone Binding Chromo Shadow Domain Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Cilium Assembly Cell Division	DNA Repair DNA Methylation DNA Recombination Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Nuclear Cell Cycle DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Forebrain Development Replication Fork Processing Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Transcription From RNA Polymerase II Promoter Sertoli Cell Development Seminiferous Tubule Development Cellular Response To Hydroxyurea Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A MRE11A PPP2R5A TP53BP1 TSC2 YWHAH ZNF350	21 interactors: ATN1 BLM CALM1 CCSER2 DAXX EZH2 HDAC1 HDAC4 HIST1H3A HIST2H3C KIAA1377 LUC7L2 NEK1 NSD1 PTN PTPN4 RAD51 SVIL WRN ZBED1 ZNF512B
Entrez ID		4750	546
HPRD ID		06847	02069
Ensembl ID		ENSG00000137601	ENSG00000085224
Uniprot IDs		Q5JXL9 Q96PY6	A4LAA3 B4DLW1 P46100
PDB IDs		4APC 4B9D	2JM1 2LBM 2LD1 3QL9 3QLA 3QLC 3QLN
Enriched GO Terms of Interacting Partners?		Response To Stimulus Regulation Of Cellular Component Organization Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Nervous System Development Regulation Of Cellular Process DNA Recombination Glucocorticoid Catabolic Process Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Dendrite Morphogenesis DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Generation Of Neurons DNA Modification Neurogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Dendrite Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Lipid Kinase Activity Cellular Response To Hydroxyurea DNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Stem Cell Homeostasis Regulation Of DNA Replication Signal Transduction Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Transport Into Plasma Membrane Raft Cell Projection Organization Double-strand Break Repair System Development Regulation Of Mitotic Recombination Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Plasma Membrane Raft Regulation Of Transcription, DNA-templated Nuclear MRNA Surveillance DNA Repair Chemotaxis Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cell Communication Positive Regulation Of Transcription, DNA-templated Regulation Of Endocytosis Regulation Of RNA Metabolic Process Cullin Deneddylation	Organelle Organization Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Cellular Response To Camptothecin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Response To Camptothecin Cellular Response To Radiation Response To Ionizing Radiation Negative Regulation Of Gene Expression Cellular Response To Ionizing Radiation Nucleobase-containing Compound Metabolic Process DNA Methylation Chromatin Organization Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Radiation DNA Duplex Unwinding DNA Geometric Change Response To Stress Cellular Nitrogen Compound Metabolic Process DNA Methylation On Cytosine DNA Modification Regulation Of Cell Division Chromatin Silencing At RDNA Replication Fork Processing Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Cycle DNA-dependent DNA Replication Chromatin Modification Wound Healing Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Cycle Process Histone H4 Deacetylation DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Wounding Gene Expression Double-strand Break Repair Histone Modification
Tagcloud ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin	12v2 altering banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs nras ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Difference) ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin	12v2 altering banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs nras ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Intersection) ?