NEK1 and FEZ2

Number of citations of the paper that reports this interaction (PMID 14690447)
15

Data Source:
HPRD (two hybrid, in vitro)

		NEK1	FEZ2
Gene Name		NIMA-related kinase 1	fasciculation and elongation protein zeta 2 (zygin II)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Nucleus Cytoplasm Centrosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Cilium Assembly Cell Division	Signal Transduction Nervous System Development Axon Guidance
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A MRE11A PPP2R5A TP53BP1 TSC2 YWHAH ZNF350	18 interactors: BRD1 C16orf59 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SCOC SMC3 TBC1D25 TLK2 WWC1 ZNF251
Entrez ID		4750	9637
HPRD ID		06847	09213
Ensembl ID		ENSG00000137601	ENSG00000171055
Uniprot IDs		Q5JXL9 Q96PY6	Q9UHY8
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?		Response To Stimulus Regulation Of Cellular Component Organization Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Nervous System Development Regulation Of Cellular Process DNA Recombination Glucocorticoid Catabolic Process Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Dendrite Morphogenesis DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Generation Of Neurons DNA Modification Neurogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Dendrite Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Lipid Kinase Activity Cellular Response To Hydroxyurea DNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Stem Cell Homeostasis Regulation Of DNA Replication Signal Transduction Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Transport Into Plasma Membrane Raft Cell Projection Organization Double-strand Break Repair System Development Regulation Of Mitotic Recombination Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Plasma Membrane Raft Regulation Of Transcription, DNA-templated Nuclear MRNA Surveillance DNA Repair Chemotaxis Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cell Communication Positive Regulation Of Transcription, DNA-templated Regulation Of Endocytosis Regulation Of RNA Metabolic Process Cullin Deneddylation	Regulation Of Autophagy Regulation Of Metabolic Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Autophagy Regulation Of Cellular Process Organelle Organization Regulation Of Autophagic Vacuole Maturation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Component Organization Mitotic Nuclear Division Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell Part Morphogenesis Establishment Of Cell Polarity Positive Regulation Of Synaptic Transmission Membrane Depolarization Peptidyl-serine Phosphorylation Cell Division Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Activation Of Phospholipase D Activity Negative Regulation Of DNA Endoreduplication Positive Regulation Of Glutamate Secretion Chromosome Organization Regulation Of Chromatin Assembly Or Disassembly Negative Regulation Of Hippo Signaling Response To Ionizing Radiation Cell Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-13 Production Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Interleukin-5 Production Positive Regulation Of T Cell Cytokine Production
Tagcloud ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin
Tagcloud (Difference) ?		axin cdk1 crb3 dock7 dsh ezrin fip200 gadd34 gsk3 hamartin herc1 hscp immunoprecipitate melted merlin moesin nade p27kip1 p75ntr pam patj pc1 pp2ac rabaptin radixin rheb rsk1 tbc7 tuberin
Tagcloud (Intersection) ?