MEP1A and CCK

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		MEP1A	CCK
Gene Name		meprin A, alpha (PABA peptide hydrolase)	cholecystokinin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Hormone Activity Neuropeptide Hormone Activity Protein Binding
	Biological Process	Proteolysis Digestion	Behavioral Fear Response Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Appetite Positive Regulation Of Protein Oligomerization Eating Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Regulation Of Sensory Perception Of Pain
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Body mass index ( 22344221)
Protein-Protein Interactions		19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	6 interactors: CCKAR CCKBR CPE ENPEP MEP1A MEP1B
Entrez ID		4224	885
HPRD ID		02666	00321
Ensembl ID		ENSG00000112818	ENSG00000187094
Uniprot IDs		B7ZL91 Q16819	P06307 Q6FG82
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process	Digestion Cholecystokinin Signaling Pathway Peptide Hormone Processing Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Proteolysis Feeding Behavior Peptide Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Catabolic Process In Blood Hormone Metabolic Process Cytosolic Calcium Ion Homeostasis Multicellular Organismal Protein Catabolic Process Insulin Processing Multicellular Organismal Protein Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Insulin Metabolic Process Calcium Ion Homeostasis Gastric Acid Secretion Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Organ Development Peptide Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cardiac Left Ventricle Morphogenesis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Cellular Chemical Homeostasis Ion Homeostasis Behavior Toxin Transport System Development Cellular Homeostasis Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Acid Secretion Glomerulus Development Anatomical Structure Morphogenesis Multicellular Organismal Development Cell Migration Chemical Homeostasis Cardiac Ventricle Morphogenesis Cardiovascular System Development
Tagcloud ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded
Tagcloud (Difference) ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded
Tagcloud (Intersection) ?