MEP1A and PTH

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MEP1A	PTH
Gene Name		meprin A, alpha (PABA peptide hydrolase)	parathyroid hormone
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Hormone Activity Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Proteolysis Digestion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Bone Mineralization Positive Regulation Of CAMP Biosynthetic Process Response To Vitamin D Cellular Macromolecule Biosynthetic Process Response To Drug Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Response To Parathyroid Hormone Response To Fibroblast Growth Factor
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Bone mineral density ( 19874204)
Protein-Protein Interactions		19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	5 interactors: BAG6 FEZ1 MEP1A PTH1R PTH2R
Entrez ID		4224	5741
HPRD ID		02666	01345
Ensembl ID		ENSG00000112818	ENSG00000152266
Uniprot IDs		B7ZL91 Q16819	P01270
PDB IDs			1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M
Enriched GO Terms of Interacting Partners?		Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process
Tagcloud ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput
Tagcloud (Difference) ?		accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants	accurately assay coefficients commercially cr1073m detectable determining egta example fifteen fragments gave gives immunoassay immunoreactive inter interfere interfered intra p55 parathyroid pg porcine proximity scintillation simply spa spiked throughput
Tagcloud (Intersection) ?