CFHR1 and LBP

Number of citations of the paper that reports this interaction (PMID 8663389)
15

Data Source:
HPRD (in vitro)

		CFHR1	LBP
Gene Name		complement factor H-related 1	lipopolysaccharide binding protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cell Surface Extracellular Vesicular Exosome
	Molecular Function		Lipopolysaccharide Binding Receptor Binding Protein Binding Lipoteichoic Acid Binding
	Biological Process	Complement Activation	Toll-like Receptor Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Innate Immune System
Drugs
Diseases
GWAS		Complement C3 and C4 levels ( 23028341) Nephropathy ( 21399633)
Protein-Protein Interactions		4 interactors: APOA1 CFH LBP PRDX4	19 interactors: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 IRF6 PRDX4 PSMA3 PYCRL RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		3078	3929
HPRD ID		00602	07175
Ensembl ID		ENSG00000244414	ENSG00000129988
Uniprot IDs		Q03591	P18428 Q8TCF0
PDB IDs		3ZD2
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Male Germ Cell Proliferation Regulation Of Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopolysaccharide Transport Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Cytokine Production Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Regulation Of Male Germ Cell Proliferation Negative Regulation Of Interleukin-1 Secretion Regulation Of Immune System Process High-density Lipoprotein Particle Clearance Lipid Transport Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Protein Oxidation Lipid Localization Positive Regulation Of Respiratory Burst Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Protein Maturation By Protein Folding Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Phospholipid Efflux Complement Activation, Alternative Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interleukin-1 Beta Production I-kappaB Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway High-density Lipoprotein Particle Remodeling Leukocyte Migration Involved In Inflammatory Response	Immune System Process Immune Response Regulation Of Interleukin-1 Beta Production Regulation Of Cell Proliferation Humoral Immune Response Protein Stabilization Response To Stress Regulation Of Protein Stability Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Immune System Process Posttranscriptional Regulation Of Gene Expression Regulation Of Immune Response Positive Regulation Of Stress Fiber Assembly Response To Stimulus Negative Regulation Of Protein Metabolic Process Positive Regulation Of Actin Filament Bundle Assembly Gene Expression Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Growth Of Symbiont On Or Near Host Surface Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production I-kappaB Kinase/NF-kappaB Signaling Cell Cycle Process Regulation Of Stress Fiber Assembly Regulation Of Inflammatory Response Negative Regulation Of Cell Proliferation Regulation Of Opsonization Intracellular Sequestering Of Iron Ion Negative Regulation Of Interleukin-1 Beta Secretion Sister Chromatid Biorientation Response To Other Organism Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Male Germ Cell Proliferation Evasion Or Tolerance Of Host Defenses By Virus Response To Biotic Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Negative Regulation Of Inflammatory Response
Tagcloud ?		2d apoa1 apoa4 biochemistry bioinformatic clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur	adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals
Tagcloud (Difference) ?		2d apoa1 apoa4 biochemistry bioinformatic clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur	adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals
Tagcloud (Intersection) ?