CFHR1 and PRDX4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CFHR1	PRDX4
Gene Name		complement factor H-related 1	peroxiredoxin 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Nucleus Mitochondrion Smooth Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Thioredoxin Peroxidase Activity Protein Homodimerization Activity
	Biological Process	Complement Activation	I-kappaB Phosphorylation Spermatogenesis Male Gonad Development 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Male Germ Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Complement C3 and C4 levels ( 23028341) Nephropathy ( 21399633)
Protein-Protein Interactions		4 interactors: APOA1 CFH LBP PRDX4	24 interactors: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 COX1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 VTN
Entrez ID		3078	10549
HPRD ID		00602	05935
Ensembl ID		ENSG00000244414	ENSG00000123131
Uniprot IDs		Q03591	Q13162
PDB IDs		3ZD2	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS
Enriched GO Terms of Interacting Partners?		Regulation Of Inflammatory Response Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Male Germ Cell Proliferation Regulation Of Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopolysaccharide Transport Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Cytokine Production Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Regulation Of Male Germ Cell Proliferation Negative Regulation Of Interleukin-1 Secretion Regulation Of Immune System Process High-density Lipoprotein Particle Clearance Lipid Transport Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Protein Oxidation Lipid Localization Positive Regulation Of Respiratory Burst Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Protein Maturation By Protein Folding Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Phospholipid Efflux Complement Activation, Alternative Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interleukin-1 Beta Production I-kappaB Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway High-density Lipoprotein Particle Remodeling Leukocyte Migration Involved In Inflammatory Response	Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Response To Stress Hydrogen Peroxide Metabolic Process Immune System Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Catabolic Process Reactive Oxygen Species Metabolic Process Defense Response Removal Of Superoxide Radicals Response To Lipopolysaccharide Cellular Response To Superoxide Response To Molecule Of Bacterial Origin Xenobiotic Metabolic Process Negative Regulation Of Proteolysis Cellular Response To Xenobiotic Stimulus Response To Superoxide Response To Oxygen Radical Regulation Of Proteolysis Response To Xenobiotic Stimulus Negative Regulation Of Protein Processing Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Processing Response To Stimulus Bile Acid Metabolic Process Blood Coagulation Hemostasis Superoxide Metabolic Process Platelet Activation Innate Immune Response Cell Migration Positive Regulation Of Wound Healing Response To Lipid Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thromboxane A2 Signaling Pathway Hsp90 Deacetylation Immune Response Response To Bacterium Carbohydrate Derivative Transport Leukocyte Migration Negative Regulation Of Blood Coagulation Cell Motility Negative Regulation Of Coagulation Steroid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels
Tagcloud ?		2d apoa1 apoa4 biochemistry bioinformatic clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Difference) ?		2d apoa1 apoa4 biochemistry bioinformatic clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Intersection) ?