GNAS and CRHR1

Number of citations of the paper that reports this interaction (PMID 10598591)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GNAS	CRHR1
Gene Name		GNAS complex locus	corticotropin releasing hormone receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Multivesicular Body Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Intrinsic Component Of Plasma Membrane Vesicle Neuronal Cell Body Apical Part Of Cell
	Molecular Function	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding Protein Binding Corticotrophin-releasing Factor Receptor Activity Protein Complex Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding
	Biological Process	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Response To Hypoxia Immune Response Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Female Pregnancy Parturition Memory Visual Learning Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Hypothalamus Development Adrenal Gland Development Epithelial Cell Differentiation Negative Regulation Of Epinephrine Secretion Locomotory Exploration Behavior Response To Immobilization Stress Fear Response Positive Regulation Of Mast Cell Degranulation Behavioral Response To Cocaine Behavioral Response To Ethanol Behavioral Response To Pain Corticotropin Secretion Response To Electrical Stimulus General Adaptation Syndrome, Behavioral Process Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Feeding Behavior Regulation Of Corticosterone Secretion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)	Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Head circumference (infant) ( 22504419) Intracranial volume ( 22504418)
Protein-Protein Interactions		31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1	9 interactors: CALM1 CRH GNAI1 GNAO1 GNAQ GNAS SRPK1 UCN UCN3
Entrez ID		2778	1394
HPRD ID		00761	08830
Ensembl ID		ENSG00000087460	ENSG00000120088
Uniprot IDs		O95467 P63092 P84996 Q5JWF2	B3TIK8 G3CIS4 P34998
PDB IDs			2L27 3EHS 3EHT 3EHU 4K5Y
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Response To Stress Regulation Of CAMP Metabolic Process Response To Corticosterone Dopamine Receptor Signaling Pathway Response To Organic Cyclic Compound Response To Glucocorticoid Response To Corticosteroid Response To Mineralocorticoid Response To Hormone Regulation Of Calcium Ion Transport Platelet Activation Regulation Of Cellular Localization Positive Regulation Of Corticotropin Secretion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Body Fluid Levels Regulation Of Corticotropin Secretion Signal Transduction Regulation Of Hormone Secretion Signaling Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Cell Communication Positive Regulation Of Peptide Secretion Response To Organic Substance Positive Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Hormone Secretion Negative Regulation Of Transport Cellular Response To Stimulus Blood Coagulation Positive Regulation Of Calcium Ion Import Hemostasis Response To Steroid Hormone Cell Surface Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Calcium Ion Import Response To Immobilization Stress Behavior Wound Healing Activation Of Adenylate Cyclase Activity
Tagcloud ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant
Tagcloud (Difference) ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant
Tagcloud (Intersection) ?