CRHR1 and GNAQ

Number of citations of the paper that reports this interaction (PMID 10598591)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CRHR1	GNAQ
Gene Name		corticotropin releasing hormone receptor 1	guanine nucleotide binding protein (G protein), q polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Intrinsic Component Of Plasma Membrane Vesicle Neuronal Cell Body Apical Part Of Cell	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Corticotrophin-releasing Factor Receptor Activity Protein Complex Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Immune Response Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Female Pregnancy Parturition Memory Visual Learning Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Hypothalamus Development Adrenal Gland Development Epithelial Cell Differentiation Negative Regulation Of Epinephrine Secretion Locomotory Exploration Behavior Response To Immobilization Stress Fear Response Positive Regulation Of Mast Cell Degranulation Behavioral Response To Cocaine Behavioral Response To Ethanol Behavioral Response To Pain Corticotropin Secretion Response To Electrical Stimulus General Adaptation Syndrome, Behavioral Process Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Feeding Behavior Regulation Of Corticosterone Secretion	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Head circumference (infant) ( 22504419) Intracranial volume ( 22504418)
Protein-Protein Interactions		9 interactors: CALM1 CRH GNAI1 GNAO1 GNAQ GNAS SRPK1 UCN UCN3	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		1394	2776
HPRD ID		08830	02998
Ensembl ID		ENSG00000120088
Uniprot IDs		B3TIK8 G3CIS4 P34998	P50148
PDB IDs		2L27 3EHS 3EHT 3EHU 4K5Y
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Response To Stress Regulation Of CAMP Metabolic Process Response To Corticosterone Dopamine Receptor Signaling Pathway Response To Organic Cyclic Compound Response To Glucocorticoid Response To Corticosteroid Response To Mineralocorticoid Response To Hormone Regulation Of Calcium Ion Transport Platelet Activation Regulation Of Cellular Localization Positive Regulation Of Corticotropin Secretion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Body Fluid Levels Regulation Of Corticotropin Secretion Signal Transduction Regulation Of Hormone Secretion Signaling Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Cell Communication Positive Regulation Of Peptide Secretion Response To Organic Substance Positive Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Hormone Secretion Negative Regulation Of Transport Cellular Response To Stimulus Blood Coagulation Positive Regulation Of Calcium Ion Import Hemostasis Response To Steroid Hormone Cell Surface Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Calcium Ion Import Response To Immobilization Stress Behavior Wound Healing Activation Of Adenylate Cyclase Activity	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant	adaptor contributing driving flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?		extensively