GNAS and ADCY5

Number of citations of the paper that reports this interaction (PMID 9268375)
24

Data Source:
HPRD (in vitro)

		GNAS	ADCY5
Gene Name		GNAS complex locus	adenylate cyclase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Primary Cilium
	Molecular Function	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Adenosine Receptor Signaling Pathway Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neuromuscular Process Controlling Balance Transmembrane Transport Cellular Response To Glucagon Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Phospholipase C-mediated cascade Integration of energy metabolism Signaling by FGFR in disease Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Adrenaline,noradrenaline inhibits insulin secretion Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)	Birth weight ( 23202124 20372150) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22693455)
Protein-Protein Interactions		31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1	7 interactors: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2
Entrez ID		2778	111
HPRD ID		00761	08973
Ensembl ID		ENSG00000087460	ENSG00000173175
Uniprot IDs		O95467 P63092 P84996 Q5JWF2	B3KWA8 B7Z2C7 O95622
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity	Regulation Of Phospholipase Activity Platelet Activation Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Energy Reserve Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Hydrolase Activity Response To Peptide Hormone Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Response To Peptide Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Synaptic Transmission Water Transport Histone H3-T6 Phosphorylation Wound Healing Fluid Transport Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Response To Glucagon Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Positive Regulation Of Phospholipase C Activity Regulation Of Glucose Import Regulation Of Adenylate Cyclase Activity Positive Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Kinase Activity Positive Regulation Of CAMP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Organonitrogen Compound Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Peptide Negative Regulation Of Protein Phosphorylation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of MAP Kinase Activity
Tagcloud ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating
Tagcloud (Difference) ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	acts dephosphorylating downregulating enhancing extend extends facilitated facilitating foxo3 fractions hif1alpha irs1 lc3b lifespan longevity mir mkp7 mtor pleiotropically pras40 promoted repressed repression rgs2 senescence ser2248 thr246 translocated upregulating
Tagcloud (Intersection) ?