CRHR1 and UCN3

Number of citations of the paper that reports this interaction (PMID 11416224)
149

Data Source:
HPRD (in vitro)

		CRHR1	UCN3
Gene Name		corticotropin releasing hormone receptor 1	urocortin 3
Image
Gene Ontology Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Intrinsic Component Of Plasma Membrane Vesicle Neuronal Cell Body Apical Part Of Cell	Extracellular Space Varicosity Axon Terminus
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Corticotrophin-releasing Factor Receptor Activity Protein Complex Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding	G-protein Coupled Receptor Binding Hormone Activity Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Response To Hypoxia Immune Response Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Female Pregnancy Parturition Memory Visual Learning Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Hypothalamus Development Adrenal Gland Development Epithelial Cell Differentiation Negative Regulation Of Epinephrine Secretion Locomotory Exploration Behavior Response To Immobilization Stress Fear Response Positive Regulation Of Mast Cell Degranulation Behavioral Response To Cocaine Behavioral Response To Ethanol Behavioral Response To Pain Corticotropin Secretion Response To Electrical Stimulus General Adaptation Syndrome, Behavioral Process Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Feeding Behavior Regulation Of Corticosterone Secretion	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Digestion Response To Glucose Cellular Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Immobilization Stress Response To Starvation Positive Regulation Of Membrane Potential Response To Corticosterone Cellular Response To Hypoxia
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Head circumference (infant) ( 22504419) Intracranial volume ( 22504418)	Intelligence ( 22449649)
Protein-Protein Interactions		9 interactors: CALM1 CRH GNAI1 GNAO1 GNAQ GNAS SRPK1 UCN UCN3	3 interactors: CRHR1 CRHR2 IL10RB
Entrez ID		1394	114131
HPRD ID		08830	12066
Ensembl ID		ENSG00000120088	ENSG00000178473
Uniprot IDs		B3TIK8 G3CIS4 P34998	Q969E3
PDB IDs		2L27 3EHS 3EHT 3EHU 4K5Y	2RMH 3N93
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Response To Stress Regulation Of CAMP Metabolic Process Response To Corticosterone Dopamine Receptor Signaling Pathway Response To Organic Cyclic Compound Response To Glucocorticoid Response To Corticosteroid Response To Mineralocorticoid Response To Hormone Regulation Of Calcium Ion Transport Platelet Activation Regulation Of Cellular Localization Positive Regulation Of Corticotropin Secretion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Body Fluid Levels Regulation Of Corticotropin Secretion Signal Transduction Regulation Of Hormone Secretion Signaling Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Cell Communication Positive Regulation Of Peptide Secretion Response To Organic Substance Positive Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Hormone Secretion Negative Regulation Of Transport Cellular Response To Stimulus Blood Coagulation Positive Regulation Of Calcium Ion Import Hemostasis Response To Steroid Hormone Cell Surface Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Calcium Ion Import Response To Immobilization Stress Behavior Wound Healing Activation Of Adenylate Cyclase Activity	Cellular Response To Corticotropin-releasing Hormone Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger General Adaptation Syndrome, Behavioral Process Corticotropin Secretion General Adaptation Syndrome Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Corticosterone Secretion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Epinephrine Secretion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Feeding Behavior Negative Regulation Of CAMP-mediated Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Organic Substance Locomotory Exploration Behavior Behavioral Response To Ethanol Positive Regulation Of Mast Cell Degranulation Regulation Of Feeding Behavior Positive Regulation Of CAMP-mediated Signaling Behavioral Response To Cocaine Positive Regulation Of Mast Cell Activation Cellular Response To Hormone Stimulus Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Parturition Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Positive Regulation Of Regulated Secretory Pathway Regulation Of Voltage-gated Calcium Channel Activity Behavioral Response To Pain Regulation Of CAMP-mediated Signaling Response To Immobilization Stress Hypothalamus Development Regulation Of Mast Cell Degranulation Exploration Behavior Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Response To Hormone Regulation Of Regulated Secretory Pathway Adrenal Gland Development Response To Pain Fear Response Negative Regulation Of Transporter Activity
Tagcloud ?		allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 urocortins vasodilation
Tagcloud (Difference) ?		allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 urocortins vasodilation
Tagcloud (Intersection) ?