GNAS and AVPR2

Number of citations of the paper that reports this interaction (PMID 15782186)
67

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo)

		GNAS	AVPR2
Gene Name		GNAS complex locus	arginine vasopressin receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Vasopressin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Water Transport Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Telencephalon Development Positive Regulation Of Protein Ubiquitination Interferon-gamma Production Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction Transmembrane Transport Response To Peptide
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Aquaporin-mediated transport GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors
Drugs			Desmopressin Vasopressin Conivaptan Terlipressin Tolvaptan
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1	7 interactors: ARRB2 AVP C1QTNF1 GNAS GNB1 GNG2 GRK5
Entrez ID		2778	554
HPRD ID		00761	02368
Ensembl ID		ENSG00000087460	ENSG00000126895
Uniprot IDs		O95467 P63092 P84996 Q5JWF2	P30518
PDB IDs			4JQI
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity	Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Platelet Activation Regulation Of Body Fluid Levels Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Glucagon Response To Fatty Acid Generation Of Precursor Metabolites And Energy Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Acid Chemical Wound Healing Cytosolic Calcium Ion Homeostasis Regulation Of Signal Transduction Cell Activation Response To Wounding Renal Water Homeostasis Regulation Of Signaling Negative Regulation Of Mitochondrion Organization Response To Organonitrogen Compound Response To Lipid Chemical Homeostasis Response To Organic Cyclic Compound Cellular Calcium Ion Homeostasis Water Transport Energy Derivation By Oxidation Of Organic Compounds Calcium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Response To Hormone Fluid Transport Cellular Response To Peptide Apoptotic Process Multicellular Organismal Water Homeostasis Programmed Cell Death Cell Death Death Water Homeostasis
Tagcloud ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Difference) ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Intersection) ?