GNAS and PTGDR

Number of citations of the paper that reports this interaction (PMID 12672054)
10

Data Source:
HPRD (in vivo)

		GNAS	PTGDR
Gene Name		GNAS complex locus	prostaglandin D2 receptor (DP)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Prostaglandin J Receptor Activity Prostaglandin D Receptor Activity Protein Binding
	Biological Process	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Inflammatory Response G-protein Coupled Receptor Signaling Pathway Male Sex Determination Sleep Adenosine Metabolic Process Cellular Response To Prostaglandin D Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs			Nedocromil
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1	3 interactors: ANKRD13C APP GNAS
Entrez ID		2778	5729
HPRD ID		00761	05254
Ensembl ID		ENSG00000087460	ENSG00000168229
Uniprot IDs		O95467 P63092 P84996 Q5JWF2	G3V5L3 Q13258
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity	Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Developmental Growth Cognition Regulation Of Developmental Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Blood Coagulation Hemostasis Cellular Localization Neuron Remodeling Protein Retention In ER Lumen Growth Maintenance Of Protein Localization In Endoplasmic Reticulum Secretion By Cell Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Positive Regulation Of CAMP-mediated Signaling Regulation Of Body Fluid Levels Wound Healing Adrenergic Receptor Signaling Pathway Regulation Of Growth Regulation Of Receptor Biosynthetic Process Secretion Hair Follicle Placode Formation Regulation Of Anoikis Cellular Copper Ion Homeostasis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cell Activation Response To Wounding Negative Regulation Of Multicellular Organism Growth Regulation Of CAMP-mediated Signaling CAMP Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Osteoclast Differentiation Cellular Response To Catecholamine Stimulus Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Neuron Maturation MRNA Polyadenylation
Tagcloud ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	ah ajap1 atypical biomarker biopsy bisulfite confirm conversion ec endometrial fourteen gynecologic hs3st2 hypermethylation hyperplasia hysterectomy methylated methylation methylomic microarray predict predictive sox1 sparing testing undergoing validation value warranted
Tagcloud (Difference) ?		accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields	ah ajap1 atypical biomarker biopsy bisulfite confirm conversion ec endometrial fourteen gynecologic hs3st2 hypermethylation hyperplasia hysterectomy methylated methylation methylomic microarray predict predictive sox1 sparing testing undergoing validation value warranted
Tagcloud (Intersection) ?