DLG2 and FZD7

Number of citations of the paper that reports this interaction (PMID 12067714)
9

Data Source:
HPRD (two hybrid)

		DLG2	FZD7
Gene Name		discs, large homolog 2 (Drosophila)	frizzled class receptor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding	G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Mesenchymal To Epithelial Transition Cellular Response To Retinoic Acid
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Asymmetric localization of PCP proteins Signaling by Wnt Metabolic disorders of biological oxidation enzymes GPCR ligand binding PCP/CE pathway Class B/2 (Secretin family receptors) beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A	6 interactors: DLG1 DLG2 DLG4 MAGI3 UBQLN1 UBQLN4
Entrez ID		1740	8324
HPRD ID		04663	04560
Ensembl ID		ENSG00000150672	ENSG00000155760
Uniprot IDs		B7Z2T4 E9PN83 Q15700	O75084
PDB IDs		2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Organophosphate Metabolic Process Protein Localization To Membrane Synaptic Transmission Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Cellular Protein Metabolic Process Membrane Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cell-cell Signaling T Cell Cytokine Production Small Molecule Metabolic Process Regulation Of Catalytic Activity Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Regulation Of Membrane Potential Negative Regulation Of Receptor Internalization Regulation Of Signal Transduction Peristalsis Cytokine Production Involved In Immune Response Immunological Synapse Formation Locomotory Exploration Behavior Phosphate-containing Compound Metabolic Process Dendritic Spine Morphogenesis Synaptic Vesicle Maturation Maintenance Of Cell Polarity Cellular Protein Localization Regulation Of Signaling Vocalization Behavior Amyloid Precursor Protein Metabolic Process Axon Guidance Regulation Of Phosphorus Metabolic Process Membrane Raft Organization Dendritic Spine Development Endothelial Cell Proliferation Regulation Of Ion Transmembrane Transport Positive Regulation Of Catalytic Activity Negative Regulation Of Receptor-mediated Endocytosis
Tagcloud ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	199a 5p aberrant aberrantly biomarker called carcinogenesis elucidate fresh frizzled growing hcc hepatocarcinogenesis hepatocellular importantly indicates inversely jun mir mirnas perspective precise regulators restoration showing strengthened theoretical tumorigenesis wnt
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	199a 5p aberrant aberrantly biomarker called carcinogenesis elucidate fresh frizzled growing hcc hepatocarcinogenesis hepatocellular importantly indicates inversely jun mir mirnas perspective precise regulators restoration showing strengthened theoretical tumorigenesis wnt
Tagcloud (Intersection) ?