RPS6KC1 and SPHK1

Number of citations of the paper that reports this interaction (PMID 12077123)
13

Data Source:
HPRD (two hybrid, in vivo)

		RPS6KC1	SPHK1
Gene Name		ribosomal protein S6 kinase, 52kDa, polypeptide 1	sphingosine kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Axon
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol Binding	Magnesium Ion Binding DNA Binding NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Protein Phosphatase 2A Binding
	Biological Process	Protein Phosphorylation Signal Transduction	Blood Vessel Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Protein Folding Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Brain Development Female Pregnancy Cellular Response To Starvation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Response To Amine Cyclooxygenase Pathway Calcium-mediated Signaling Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Response To Magnesium Ion Response To Progesterone Regulation Of Interleukin-1 Beta Production Response To ATP Intracellular Signal Transduction Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingoid Catabolic Process Lipid Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation 'de Novo' Posttranslational Protein Folding Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Cellular Response To Growth Factor Stimulus
Pathways			Sphingolipid metabolism Protein folding Metabolism of lipids and lipoproteins VEGFR2 mediated cell proliferation Signaling by VEGF Sphingolipid de novo biosynthesis Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PBX2 PRDX3 SPHK1	12 interactors: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6
Entrez ID		26750	8877
HPRD ID		10204	04768
Ensembl ID		ENSG00000136643	ENSG00000176170
Uniprot IDs		F5H7T0 Q96S38	Q53ZR5 Q9NYA1
PDB IDs			3VZB 3VZC 3VZD 4L02
Enriched GO Terms of Interacting Partners?		Cellular Response To Reactive Oxygen Species Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Sphingoid Catabolic Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Peptidyl-cysteine Oxidation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Female Pregnancy Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Oxidation Response To Oxidative Stress Response To Inorganic Substance Sphingosine Metabolic Process Positive Regulation Of Neurotransmitter Secretion Cyclooxygenase Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Magnesium Ion Hydrogen Peroxide Catabolic Process Prostaglandin Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Response To ATP Positive Regulation Of Smooth Muscle Contraction Prostaglandin Metabolic Process Positive Regulation Of Cell Proliferation Sphingolipid Catabolic Process Response To Lipid Membrane Lipid Catabolic Process Regulation Of Mitochondrial Membrane Potential Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cell Death Regulation Of NF-kappaB Import Into Nucleus Maternal Placenta Development Icosanoid Biosynthetic Process Regulation Of Interleukin-1 Beta Production Proximal/distal Pattern Formation Regulation Of Transcription, DNA-templated Response To Amine Response To Progesterone Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Regulation Of Smooth Muscle Contraction Regulation Of RNA Metabolic Process 'de Novo' Posttranslational Protein Folding Cellular Response To Hydrogen Peroxide	Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Organic Substance Signal Transduction Activation Of Innate Immune Response NIK/NF-kappaB Signaling Immune Response Defense Response Signaling Cell Communication Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Regulation Of Cell Death Positive Regulation Of Homotypic Cell-cell Adhesion TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Organic Substance Cellular Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immunoglobulin Secretion Regulation Of Immune System Process Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell-cell Adhesion Immune System Process Positive Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Binding Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Lymphocyte Activation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death
Tagcloud ?		braf cure epha3 exons flt3 glioblastoma glioblastomas gliomagenesis hgg idh1 idh2 mapping mining mutated mutational nras offer opportunities pi3k pik3ca pten rational relapsing sequenced somatic synonymous tgfbr2 tp53 twice	acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar
Tagcloud (Difference) ?		braf cure epha3 exons flt3 glioblastoma glioblastomas gliomagenesis hgg idh1 idh2 mapping mining mutated mutational nras offer opportunities pi3k pik3ca pten rational relapsing sequenced somatic synonymous tgfbr2 tp53 twice	acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar
Tagcloud (Intersection) ?