SPHK1 and RARG

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPHK1	RARG
Gene Name		sphingosine kinase 1	retinoic acid receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Axon	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding DNA Binding NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Protein Phosphatase 2A Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding
	Biological Process	Blood Vessel Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Protein Folding Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Brain Development Female Pregnancy Cellular Response To Starvation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Response To Amine Cyclooxygenase Pathway Calcium-mediated Signaling Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Response To Magnesium Ion Response To Progesterone Regulation Of Interleukin-1 Beta Production Response To ATP Intracellular Signal Transduction Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingoid Catabolic Process Lipid Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation 'de Novo' Posttranslational Protein Folding Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Cellular Response To Growth Factor Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Glandular Epithelial Cell Development Retinal Pigment Epithelium Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Gene Expression Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Transmembrane Transport Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid
Pathways		Sphingolipid metabolism Protein folding Metabolism of lipids and lipoproteins VEGFR2 mediated cell proliferation Signaling by VEGF Sphingolipid de novo biosynthesis Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis VEGFA-VEGFR2 Pathway	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID
Diseases
GWAS
Protein-Protein Interactions		12 interactors: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	29 interactors: ACY3 EIF3I HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 RHPN2 RXRA RXRB RXRG SMAD3 SPHK1 SRC SRF TNIP1 ZNF576
Entrez ID		8877	5916
HPRD ID		04768	01573
Ensembl ID		ENSG00000176170	ENSG00000172819
Uniprot IDs		Q53ZR5 Q9NYA1	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		3VZB 3VZC 3VZD 4L02	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Organic Substance Signal Transduction Activation Of Innate Immune Response NIK/NF-kappaB Signaling Immune Response Defense Response Signaling Cell Communication Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Regulation Of Cell Death Positive Regulation Of Homotypic Cell-cell Adhesion TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Organic Substance Cellular Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immunoglobulin Secretion Regulation Of Immune System Process Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell-cell Adhesion Immune System Process Positive Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Binding Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Lymphocyte Activation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription, DNA-templated Response To Steroid Hormone Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process DNA-templated Transcription, Initiation Response To Hormone Gene Expression Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Lipid Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Steroid Hormone Mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Organ Development System Development Intracellular Steroid Hormone Receptor Signaling Pathway In Utero Embryonic Development Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Nucleobase-containing Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar	activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Difference) ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar	activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Intersection) ?