SPHK1 and LYN

Number of citations of the paper that reports this interaction (PMID 16316995)
49

Data Source:
HPRD (in vivo)

		SPHK1	LYN
Gene Name		sphingosine kinase 1	LYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Axon	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Mast Cell Granule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Protein Phosphatase 2A Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Enzyme Binding Ubiquitin Protein Ligase Binding Glycosphingolipid Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Blood Vessel Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Protein Folding Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Brain Development Female Pregnancy Cellular Response To Starvation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Response To Amine Cyclooxygenase Pathway Calcium-mediated Signaling Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Response To Magnesium Ion Response To Progesterone Regulation Of Interleukin-1 Beta Production Response To ATP Intracellular Signal Transduction Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingoid Catabolic Process Lipid Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation 'de Novo' Posttranslational Protein Folding Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Cellular Response To Growth Factor Stimulus	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Cytokine Secretion Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Peptide Hormone Stimulus Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Sphingolipid metabolism Protein folding Metabolism of lipids and lipoproteins VEGFR2 mediated cell proliferation Signaling by VEGF Sphingolipid de novo biosynthesis Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis VEGFA-VEGFR2 Pathway	Signaling by the B Cell Receptor (BCR) Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation Signaling by SCF-KIT EPHB-mediated forward signaling EPHA-mediated growth cone collapse Regulation of KIT signaling FCERI mediated NF-kB activation EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System CD28 co-stimulation CTLA4 inhibitory signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Growth hormone receptor signaling
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		12 interactors: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	115 interactors: ACTB ADAM15 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		8877	4067
HPRD ID		04768	01301
Ensembl ID		ENSG00000176170	ENSG00000254087
Uniprot IDs		Q53ZR5 Q9NYA1	A8K379 P07948 Q6NUK7
PDB IDs		3VZB 3VZC 3VZD 4L02	1W1F 1WA7 3A4O
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Organic Substance Signal Transduction Activation Of Innate Immune Response NIK/NF-kappaB Signaling Immune Response Defense Response Signaling Cell Communication Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Regulation Of Cell Death Positive Regulation Of Homotypic Cell-cell Adhesion TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Organic Substance Cellular Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immunoglobulin Secretion Regulation Of Immune System Process Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell-cell Adhesion Immune System Process Positive Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Binding Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Lymphocyte Activation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death	Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Intracellular Signal Transduction Positive Regulation Of Immune System Process Defense Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cell Activation Regulation Of Signaling Response To Organic Substance Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Locomotion Positive Regulation Of Protein Modification Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Blood Coagulation Positive Regulation Of Protein Phosphorylation Movement Of Cell Or Subcellular Component Hemostasis Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Platelet Activation
Tagcloud ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar	5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated
Tagcloud (Difference) ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar	5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated
Tagcloud (Intersection) ?