SPHK1 and SPHKAP

Number of citations of the paper that reports this interaction (PMID 12080051)
15

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SPHK1	SPHKAP
Gene Name		sphingosine kinase 1	SPHK1 interactor, AKAP domain containing
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Axon	Mitochondrion Z Disc Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Protein Phosphatase 2A Binding	Protein Binding Protein Kinase A Binding
	Biological Process	Blood Vessel Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Protein Folding Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Brain Development Female Pregnancy Cellular Response To Starvation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Response To Amine Cyclooxygenase Pathway Calcium-mediated Signaling Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Response To Magnesium Ion Response To Progesterone Regulation Of Interleukin-1 Beta Production Response To ATP Intracellular Signal Transduction Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingoid Catabolic Process Lipid Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation 'de Novo' Posttranslational Protein Folding Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Cellular Response To Growth Factor Stimulus	Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase A Signaling
Pathways		Sphingolipid metabolism Protein folding Metabolism of lipids and lipoproteins VEGFR2 mediated cell proliferation Signaling by VEGF Sphingolipid de novo biosynthesis Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		12 interactors: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	2 interactors: LNX1 SPHK1
Entrez ID		8877	80309
HPRD ID		04768	18052
Ensembl ID		ENSG00000176170	ENSG00000153820
Uniprot IDs		Q53ZR5 Q9NYA1	Q2M3C7
PDB IDs		3VZB 3VZC 3VZD 4L02
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Organic Substance Signal Transduction Activation Of Innate Immune Response NIK/NF-kappaB Signaling Immune Response Defense Response Signaling Cell Communication Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Regulation Of Cell Death Positive Regulation Of Homotypic Cell-cell Adhesion TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Organic Substance Cellular Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immunoglobulin Secretion Regulation Of Immune System Process Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell-cell Adhesion Immune System Process Positive Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Binding Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Lymphocyte Activation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death	Sphingoid Catabolic Process Sphingosine Metabolic Process Positive Regulation Of Neurotransmitter Secretion Cyclooxygenase Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Magnesium Ion Prostaglandin Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Response To ATP Positive Regulation Of Smooth Muscle Contraction Prostaglandin Metabolic Process Sphingolipid Catabolic Process Membrane Lipid Catabolic Process Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of NF-kappaB Import Into Nucleus Icosanoid Biosynthetic Process Regulation Of Interleukin-1 Beta Production Response To Amine Response To Progesterone Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Unsaturated Fatty Acid Biosynthetic Process Regulation Of Smooth Muscle Contraction 'de Novo' Posttranslational Protein Folding Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Hydrogen Peroxide 'de Novo' Protein Folding Arachidonic Acid Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Neurotransmitter Secretion Catabolic Process Sphingolipid Biosynthetic Process Response To Interleukin-1 Regulation Of Transcription Factor Import Into Nucleus Lipid Phosphorylation Calcium-mediated Signaling Positive Regulation Of Protein Import Into Nucleus Icosanoid Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Fibroblast Proliferation Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Unsaturated Fatty Acid Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Synaptic Transmission Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Growth Long-chain Fatty Acid Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide
Tagcloud ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar
Tagcloud (Difference) ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar
Tagcloud (Intersection) ?