SPHK1 and CTSB

Number of citations of the paper that reports this interaction (PMID 15710602)
18

Data Source:
HPRD (in vitro)

		SPHK1	CTSB
Gene Name		sphingosine kinase 1	cathepsin B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Axon	Extracellular Region Extracellular Space Intracellular Nucleolus Mitochondrion Lysosome Endolysosome Lumen Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Protein Phosphatase 2A Binding	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Blood Vessel Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Protein Folding Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Brain Development Female Pregnancy Cellular Response To Starvation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Response To Amine Cyclooxygenase Pathway Calcium-mediated Signaling Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Response To Magnesium Ion Response To Progesterone Regulation Of Interleukin-1 Beta Production Response To ATP Intracellular Signal Transduction Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingoid Catabolic Process Lipid Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation 'de Novo' Posttranslational Protein Folding Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Cellular Response To Growth Factor Stimulus	Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Innate Immune Response Decidualization Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Sphingolipid metabolism Protein folding Metabolism of lipids and lipoproteins VEGFR2 mediated cell proliferation Signaling by VEGF Sphingolipid de novo biosynthesis Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis VEGFA-VEGFR2 Pathway	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation Collagen degradation MHC class II antigen presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System
Drugs			2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic Acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases
GWAS
Protein-Protein Interactions		12 interactors: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	33 interactors: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD FAM118B HNRNPD IGF1 INS MARCKS PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 UBQLN4 XRN1
Entrez ID		8877	1508
HPRD ID		04768	00287
Ensembl ID		ENSG00000176170	ENSG00000164733
Uniprot IDs		Q53ZR5 Q9NYA1	P07858
PDB IDs		3VZB 3VZC 3VZD 4L02	1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Organic Substance Signal Transduction Activation Of Innate Immune Response NIK/NF-kappaB Signaling Immune Response Defense Response Signaling Cell Communication Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Regulation Of Cell Death Positive Regulation Of Homotypic Cell-cell Adhesion TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Organic Substance Cellular Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immunoglobulin Secretion Regulation Of Immune System Process Regulation Of Signaling Regulation Of Protein Localization Regulation Of Cell-cell Adhesion Immune System Process Positive Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Binding Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Lymphocyte Activation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death	Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Binding Regulation Of Growth Regulation Of Cellular Process Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Binding Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Coagulation Positive Regulation Of Cell Cycle Developmental Process Negative Regulation Of Wound Healing Organ Development Negative Regulation Of MAPK Cascade Response To Abiotic Stimulus Regulation Of Protein Import Into Nucleus Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus
Tagcloud ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar	bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1p s1pr1 s1pr3 saline sphingosine synthesizing tubulointerstitium wistar	bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?