EFNB1 and SORBS1

Number of citations of the paper that reports this interaction (PMID 11557983)
72

Data Source:
HPRD (in vivo)

		EFNB1	SORBS1
Gene Name		ephrin-B1	sorbin and SH3 domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Synapse Extracellular Vesicular Exosome	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft
	Molecular Function	Protein Binding Ephrin Receptor Binding	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Axon Guidance Embryonic Pattern Specification Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Smooth Muscle Contraction
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ	25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL
Entrez ID		1947	10580
HPRD ID		02072	05587
Ensembl ID		ENSG00000090776	ENSG00000095637
Uniprot IDs		P98172	Q9BX66
PDB IDs			2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Axon Guidance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Neuron Projection Development Axonogenesis Cell Development Axon Development Regulation Of Organelle Organization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Stress Fiber Assembly Cell Morphogenesis Generation Of Neurons Dendritic Spine Organization Neurogenesis Nervous System Development Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Signal Transduction Cell Motility Cellular Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Apoptotic Process Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Signaling Programmed Cell Death Actin Filament-based Process Cell Communication Cell Death Death Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Organelle Organization Positive Regulation Of Transport Anatomical Structure Morphogenesis Optic Nerve Morphogenesis	Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Tagcloud ?		allow attenuation cetuximab contribution dimerization disappointing drives egf egfr ephrinb1 erbb1 head hnscc mechanistically mediate neck overexpress partner partners persistent persists rearrangements shift slowed squamous substantial targeted trigger yielded	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Difference) ?		allow attenuation cetuximab contribution dimerization disappointing drives egf egfr ephrinb1 erbb1 head hnscc mechanistically mediate neck overexpress partner partners persistent persists rearrangements shift slowed squamous substantial targeted trigger yielded	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Intersection) ?