AP2A2 and DNM1

Number of citations of the paper that reports this interaction (PMID 10430869)
41

Data Source:
HPRD (in vitro)

		AP2A2	DNM1
Gene Name		adaptor-related protein complex 2, alpha 2 subunit	dynamin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Microtubule Plasma Membrane Membrane Coat Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding Lipid Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding Protein Kinase Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding Nitric-oxide Synthase Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis	Endocytosis Receptor-mediated Endocytosis Endosome Organization Axon Guidance Receptor Internalization Ephrin Receptor Signaling Pathway Clathrin-mediated Endocytosis
Pathways		Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Retrograde neurotrophin signalling Signalling by NGF Formation of annular gap junctions Axon guidance Gap junction degradation Gap junction trafficking L1CAM interactions NGF signalling via TRKA from the plasma membrane Recycling pathway of L1 Toll-Like Receptors Cascades EPH-ephrin mediated repulsion of cells Toll Like Receptor 4 (TLR4) Cascade Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		17 interactors: AMPH AP1S1 AP2B1 APP ATM ATR BIN1 CLTC DNAJC6 DNM1 EPN1 EPS15 HTT NUMB SHC1 SMAD1 SNAP91	47 interactors: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GNB2L1 GRB2 GRIN1 GRIN2D ITSN1 KIAA1377 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I
Entrez ID		161	1759
HPRD ID		06256	03851
Ensembl ID		ENSG00000183020	ENSG00000106976
Uniprot IDs		O94973	Q05193
PDB IDs			1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Signaling Cell Communication Neuron Apoptotic Process Anatomical Structure Morphogenesis Neuron Death Transport Cell Aging Membrane Organization Replicative Senescence Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Clathrin-mediated Endocytosis Regulation Of Signal Transduction Developmental Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Transport Generation Of Neurons Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Signal Transduction By P53 Class Mediator Multicellular Organismal Development Nervous System Development Regulation Of Receptor Activity Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cellular Response To Gamma Radiation Anatomical Structure Development Regulation Of Neurogenesis Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Cellular Localization Cell Morphogenesis Involved In Differentiation Learning Notch Signaling Pathway Cell Development Axon Guidance	Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Protein Complex Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cellular Component Assembly Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Membrane Organization Transport Axon Guidance Cell Projection Organization Regulation Of Signaling Neuron Projection Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Synaptic Vesicle Transport Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Neuron Development Generation Of Neurons Membrane Tubulation Signaling Axonogenesis Anatomical Structure Development Protein Complex Assembly Neurogenesis Cell Communication Anatomical Structure Morphogenesis Locomotion Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Cell Morphogenesis Involved In Differentiation Axon Development Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Recycling Regulation Of Signal Transduction Neurotrophin Signaling Pathway Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Metabolic Process Neuron Differentiation Negative Regulation Of Endocytosis
Tagcloud ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?