AP2A2 and AP1S1

Number of citations of the paper that reports this interaction (PMID 11707398)
19

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		AP2A2	AP1S1
Gene Name		adaptor-related protein complex 2, alpha 2 subunit	adaptor-related protein complex 1, sigma 1 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Golgi Membrane Lysosomal Membrane Cytosol Coated Pit Membrane AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding Lipid Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Response To Virus Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AMPH AP1S1 AP2B1 APP ATM ATR BIN1 CLTC DNAJC6 DNM1 EPN1 EPS15 HTT NUMB SHC1 SMAD1 SNAP91	4 interactors: AP1G1 AP1G2 AP1M2 AP2A2
Entrez ID		161	1174
HPRD ID		06256	04635
Ensembl ID		ENSG00000183020	ENSG00000106367
Uniprot IDs		O94973	P61966
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Signaling Cell Communication Neuron Apoptotic Process Anatomical Structure Morphogenesis Neuron Death Transport Cell Aging Membrane Organization Replicative Senescence Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Clathrin-mediated Endocytosis Regulation Of Signal Transduction Developmental Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Transport Generation Of Neurons Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Signal Transduction By P53 Class Mediator Multicellular Organismal Development Nervous System Development Regulation Of Receptor Activity Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cellular Response To Gamma Radiation Anatomical Structure Development Regulation Of Neurogenesis Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Cellular Localization Cell Morphogenesis Involved In Differentiation Learning Notch Signaling Pathway Cell Development Axon Guidance	Regulation Of Defense Response To Virus By Virus Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Viral Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Cellular Localization Positive Regulation Of Natural Killer Cell Degranulation Golgi To Lysosome Transport Regulation Of Immune System Process Golgi Vesicle Transport Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Cellular Pigment Accumulation Transport Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Activation Clathrin-mediated Endocytosis Regulation Of Regulated Secretory Pathway Vesicle Targeting Membrane Organization Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Ephrin Receptor Signaling Pathway
Tagcloud ?			actb api5 calculating crossbred csn1s2 fabp3 gilts icg lactation ltf mined mrpl39 mtg1 normalization parturition pcsk2 ppp2r5b primiparous ptbp1 qpcr qtrt1 rps15a scd tmem24 trim41 underscore uxt vabp vapb
Tagcloud (Difference) ?			actb api5 calculating crossbred csn1s2 fabp3 gilts icg lactation ltf mined mrpl39 mtg1 normalization parturition pcsk2 ppp2r5b primiparous ptbp1 qpcr qtrt1 rps15a scd tmem24 trim41 underscore uxt vabp vapb
Tagcloud (Intersection) ?