AP2A2 and DNAJC6

Number of citations of the paper that reports this interaction (PMID 11470803)
13

Data Source:
HPRD (in vitro)

		AP2A2	DNAJC6
Gene Name		adaptor-related protein complex 2, alpha 2 subunit	DnaJ (Hsp40) homolog, subfamily C, member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Cytosol Synapse
	Molecular Function	Molecular_function Protein Binding Lipid Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Protein Tyrosine Phosphatase Activity SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis	Post-Golgi Vesicle-mediated Transport Peptidyl-tyrosine Dephosphorylation Membrane Organization Clathrin Coat Disassembly Regulation Of Clathrin-mediated Endocytosis
Pathways		Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS			Anticoagulant levels ( 22216198)
Protein-Protein Interactions		17 interactors: AMPH AP1S1 AP2B1 APP ATM ATR BIN1 CLTC DNAJC6 DNM1 EPN1 EPS15 HTT NUMB SHC1 SMAD1 SNAP91	3 interactors: AP2A2 BAG2 CLTC
Entrez ID		161	9829
HPRD ID		06256	16326
Ensembl ID		ENSG00000183020	ENSG00000116675
Uniprot IDs		O94973	O75061
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Signaling Cell Communication Neuron Apoptotic Process Anatomical Structure Morphogenesis Neuron Death Transport Cell Aging Membrane Organization Replicative Senescence Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Clathrin-mediated Endocytosis Regulation Of Signal Transduction Developmental Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Transport Generation Of Neurons Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Signal Transduction By P53 Class Mediator Multicellular Organismal Development Nervous System Development Regulation Of Receptor Activity Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cellular Response To Gamma Radiation Anatomical Structure Development Regulation Of Neurogenesis Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Cellular Localization Cell Morphogenesis Involved In Differentiation Learning Notch Signaling Pathway Cell Development Axon Guidance	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Hyaluronan Biosynthetic Process Antigen Processing And Presentation Receptor-mediated Endocytosis Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Defense Response To Virus By Virus Transferrin Transport Intracellular Protein Transport Clathrin-mediated Endocytosis Receptor Internalization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Cellular Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Iron Ion Transport Regulation Of ERBB Signaling Pathway Receptor Metabolic Process Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Intracellular Transport Ephrin Receptor Signaling Pathway
Tagcloud ?			advances autosomal bring closer determinants dj exome expectation gba genetics incomplete juvenile landscape lrrk2 modulating monogenic outline parkin parkinsonism pd penetrance penetrant pink1 recessive snca synj1 technologies variants vps35
Tagcloud (Difference) ?			advances autosomal bring closer determinants dj exome expectation gba genetics incomplete juvenile landscape lrrk2 modulating monogenic outline parkin parkinsonism pd penetrance penetrant pink1 recessive snca synj1 technologies variants vps35
Tagcloud (Intersection) ?