DNM1 and PACSIN2

Number of citations of the paper that reports this interaction (PMID 11082044)
39

Data Source:
BioGRID (pull down)

		DNM1	PACSIN2
Gene Name		dynamin 1	protein kinase C and casein kinase substrate in neurons 2
Image
Gene Ontology Annotations	Cellular Component	Microtubule Plasma Membrane Membrane Coat Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Early Endosome Cytosol Cytoskeleton Caveola Cell-cell Junction Focal Adhesion Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding Protein Kinase Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding Nitric-oxide Synthase Binding	Transporter Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding Phosphatidic Acid Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosome Organization Axon Guidance Receptor Internalization Ephrin Receptor Signaling Pathway Clathrin-mediated Endocytosis	Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Caveola Assembly Caveolin-mediated Endocytosis Membrane Tubulation
Pathways		Retrograde neurotrophin signalling Signalling by NGF Formation of annular gap junctions Axon guidance Gap junction degradation Gap junction trafficking L1CAM interactions NGF signalling via TRKA from the plasma membrane Recycling pathway of L1 Toll-Like Receptors Cascades EPH-ephrin mediated repulsion of cells Toll Like Receptor 4 (TLR4) Cascade Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		47 interactors: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GNB2L1 GRB2 GRIN1 GRIN2D ITSN1 KIAA1377 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I	12 interactors: DNM1 FASLG MEOX2 PACSIN1 PACSIN3 POT1 SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL
Entrez ID		1759	11252
HPRD ID		03851	05390
Ensembl ID		ENSG00000106976	ENSG00000100266
Uniprot IDs		Q05193	Q6FIA3 Q9UNF0
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS	3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Protein Complex Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cellular Component Assembly Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Membrane Organization Transport Axon Guidance Cell Projection Organization Regulation Of Signaling Neuron Projection Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Synaptic Vesicle Transport Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Neuron Development Generation Of Neurons Membrane Tubulation Signaling Axonogenesis Anatomical Structure Development Protein Complex Assembly Neurogenesis Cell Communication Anatomical Structure Morphogenesis Locomotion Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Cell Morphogenesis Involved In Differentiation Axon Development Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Recycling Regulation Of Signal Transduction Neurotrophin Signaling Pathway Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Metabolic Process Neuron Differentiation Negative Regulation Of Endocytosis	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Regulation Of Endocytosis Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Telomere Maintenance Endocytosis Negative Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Membrane Tubulation Regulation Of Telomerase Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Positive Regulation Of Protein Depolymerization Endomembrane System Organization Regulation Of Organelle Organization Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Complex Disassembly Endosome Organization Establishment Of Vesicle Localization Positive Regulation Of Cytoskeleton Organization Synaptic Vesicle Endocytosis Regulation Of Chromosome Organization Vesicle Localization Synaptic Vesicle Recycling Negative Regulation Of Endocytosis Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Homeostatic Process Actin Filament Organization Vesicle-mediated Transport Establishment Of Organelle Localization Positive Regulation Of Synaptic Vesicle Uncoating Cortical Microtubule Organization Synaptic Vesicle Uncoating Positive Regulation Of DNA Strand Elongation Primary Spermatocyte Growth Osmosensory Signaling Pathway Negative Regulation Of DNA Recombination At Telomere Regulation Of Synaptic Vesicle Membrane Organization Regulation Of Microtubule Polymerization Or Depolymerization Cell-cell Signaling
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	abolished apo bidirectional cd178 cd95 cd95l constructs correspond cytosolic fas fbp17 fingerprints formin fragments grb2 homology lysates mediator overexpressed polyproline precipitate precipitates respective sh3 stimulatory tail trafficking tubulin
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	abolished apo bidirectional cd178 cd95 cd95l constructs correspond cytosolic fas fbp17 fingerprints formin fragments grb2 homology lysates mediator overexpressed polyproline precipitate precipitates respective sh3 stimulatory tail trafficking tubulin
Tagcloud (Intersection) ?