AP2A2 and SNAP91

Number of citations of the paper that reports this interaction (PMID 10430869)
41

Data Source:
HPRD (in vitro)

		AP2A2	SNAP91
Gene Name		adaptor-related protein complex 2, alpha 2 subunit	synaptosomal-associated protein, 91kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Plasma Membrane Coated Pit Clathrin-coated Vesicle
	Molecular Function	Molecular_function Protein Binding Lipid Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Protein Binding 1-phosphatidylinositol Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis	Synaptic Transmission Protein Transport Clathrin Coat Assembly Regulation Of Clathrin-mediated Endocytosis
Pathways		Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		17 interactors: AMPH AP1S1 AP2B1 APP ATM ATR BIN1 CLTC DNAJC6 DNM1 EPN1 EPS15 HTT NUMB SHC1 SMAD1 SNAP91	8 interactors: AP2A2 AP2B1 EPS15 NECAP1 OGT PLCG1 TRAF3IP1 TUBA1B
Entrez ID		161	9892
HPRD ID		06256	06391
Ensembl ID		ENSG00000183020	ENSG00000065609
Uniprot IDs		O94973	B7Z2N2 O60641
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Signaling Cell Communication Neuron Apoptotic Process Anatomical Structure Morphogenesis Neuron Death Transport Cell Aging Membrane Organization Replicative Senescence Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Clathrin-mediated Endocytosis Regulation Of Signal Transduction Developmental Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Transport Generation Of Neurons Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Signal Transduction By P53 Class Mediator Multicellular Organismal Development Nervous System Development Regulation Of Receptor Activity Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cellular Response To Gamma Radiation Anatomical Structure Development Regulation Of Neurogenesis Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Cellular Localization Cell Morphogenesis Involved In Differentiation Learning Notch Signaling Pathway Cell Development Axon Guidance	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Regulation Of Immune System Process Regulation Of Defense Response To Virus By Virus Vesicle-mediated Transport Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Intracellular Transport Regulation Of Signal Transduction Clathrin-mediated Endocytosis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Signaling Transport Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Establishment Of Localization In Cell Axon Guidance Cell Morphogenesis Negative Regulation Of Signal Transduction Cell Projection Organization Negative Regulation Of Signaling Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cellular Localization Ephrin Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axonogenesis Response To Organic Substance Viral Process Protein Transport Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Protein Localization Chemotaxis Response To Growth Factor Movement Of Cell Or Subcellular Component Cytoskeleton-dependent Intracellular Transport Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Response To External Stimulus
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