DNM1 and SH3GL1

Number of citations of the paper that reports this interaction (PMID 9238017)
74

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		DNM1	SH3GL1
Gene Name		dynamin 1	SH3-domain GRB2-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Microtubule Plasma Membrane Membrane Coat Extracellular Vesicular Exosome	Podosome Cytoplasm Cell Junction Early Endosome Membrane Cell Projection
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding Protein Kinase Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding Nitric-oxide Synthase Binding	Protein Binding Lipid Binding Phosphatase Binding Identical Protein Binding GTPase Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosome Organization Axon Guidance Receptor Internalization Ephrin Receptor Signaling Pathway Clathrin-mediated Endocytosis	Endocytosis Signal Transduction Central Nervous System Development
Pathways		Retrograde neurotrophin signalling Signalling by NGF Formation of annular gap junctions Axon guidance Gap junction degradation Gap junction trafficking L1CAM interactions NGF signalling via TRKA from the plasma membrane Recycling pathway of L1 Toll-Like Receptors Cascades EPH-ephrin mediated repulsion of cells Toll Like Receptor 4 (TLR4) Cascade Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		47 interactors: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GNB2L1 GRB2 GRIN1 GRIN2D ITSN1 KIAA1377 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I	26 interactors: ARHGAP8 AXIN1 B3GAT1 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A GPKOW ITSN2 LRRK2 MAL2 MTA1 PDCD6IP PML PTPRO SEPT8 SH2D4A SH3D19 SH3GL2 SH3GL3 SYNJ1 VIM VPS37C YWHAZ
Entrez ID		1759	6455
HPRD ID		03851	03462
Ensembl ID		ENSG00000106976	ENSG00000141985
Uniprot IDs		Q05193	Q6FGM0 Q99961
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Protein Complex Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cellular Component Assembly Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Membrane Organization Transport Axon Guidance Cell Projection Organization Regulation Of Signaling Neuron Projection Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Synaptic Vesicle Transport Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Neuron Development Generation Of Neurons Membrane Tubulation Signaling Axonogenesis Anatomical Structure Development Protein Complex Assembly Neurogenesis Cell Communication Anatomical Structure Morphogenesis Locomotion Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Cell Morphogenesis Involved In Differentiation Axon Development Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Recycling Regulation Of Signal Transduction Neurotrophin Signaling Pathway Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Metabolic Process Neuron Differentiation Negative Regulation Of Endocytosis	Vesicle-mediated Transport Positive Regulation Of Protein Autoubiquitination Endocytosis Regulation Of Protein Autoubiquitination Regulation Of Cellular Component Organization Protein Localization To Mitochondrion Regulation Of Cellular Localization Regulation Of Protein Ubiquitination Cellular Localization Cell Death Death Regulation Of Mitochondrial Fission Regulation Of Signaling Organelle Organization Regulation Of Mitochondrion Organization Membrane Organization Cell Part Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Viral Process Positive Regulation Of Proteolysis Entrainment Of Circadian Clock By Photoperiod Signaling Cell Development Virion Assembly Transport Apoptotic Process Cell Communication Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Protein Ubiquitination Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Programmed Cell Death Regulation Of Vesicle-mediated Transport Signal Transduction Regulation Of Protein Catabolic Process Axon Guidance Synaptic Vesicle Endocytosis Generation Of Neurons Synaptic Vesicle Recycling Positive Regulation Of Organelle Organization Neuron Differentiation Organelle Localization Regulation Of Synaptic Vesicle Transport Regulation Of Intracellular Transport Neurogenesis Positive Regulation Of Apoptotic Signaling Pathway Neuron Projection Development Positive Regulation Of Synaptic Vesicle Uncoating
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	antigens array autoantibodies autoantibody autologous c6 clarification cloning curable deletion elicit elisa epitope establishment glioma gliomas grade grb2 homology immunological mutants oncogenic overlap serex serological spite subtle usually volunteers
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	antigens array autoantibodies autoantibody autologous c6 clarification cloning curable deletion elicit elisa epitope establishment glioma gliomas grade grb2 homology immunological mutants oncogenic overlap serex serological spite subtle usually volunteers
Tagcloud (Intersection) ?