SLC1A1 and LDLRAD1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SLC1A1	LDLRAD1
Description		solute carrier family 1 member 1	low density lipoprotein receptor class A domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Early Endosome Membrane Late Endosome Membrane Neuron Projection Synapse Recycling Endosome Membrane Extracellular Exosome	Integral Component Of Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Ion Transport Chemical Synaptic Transmission Positive Regulation Of Heart Rate Glutamate Secretion L-glutamate Transmembrane Transport Cysteine Transport L-glutamate Import D-aspartate Import Across Plasma Membrane L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Chloride Transmembrane Transport Cysteine Transmembrane Transport
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Drugs		L-Aspartic Acid Glutamic Acid
Diseases		Dicarboxylic aminoaciduria
GWAS		Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)	Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		7 interacting genes: APP ARL6IP5 EWSR1 LDLRAD1 LMNA PRKCA RNF5	16 interacting genes: ADGRG7 BNIP3 BNIP3L GIMAP5 LAPTM5 MAL MALL MARCHF2 OLFM4 PLN PTTG1IP SLC1A1 TMEM147 TMEM190 TMEM218 VTI1B
Entrez ID		6505	388633
HPRD ID		00597	17372
Ensembl ID		ENSG00000106688	ENSG00000203985
Uniprot IDs		P43005	Q5T700
PDB IDs
Enriched GO Terms of Interacting Partners?
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