SLC1A1 and EWSR1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC1A1	EWSR1
Description		solute carrier family 1 member 1	EWS RNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Early Endosome Membrane Late Endosome Membrane Neuron Projection Synapse Recycling Endosome Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Ion Transport Chemical Synaptic Transmission Positive Regulation Of Heart Rate Glutamate Secretion L-glutamate Transmembrane Transport Cysteine Transport L-glutamate Import D-aspartate Import Across Plasma Membrane L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Chloride Transmembrane Transport Cysteine Transmembrane Transport	Regulation Of Transcription, DNA-templated
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Drugs		L-Aspartic Acid Glutamic Acid
Diseases		Dicarboxylic aminoaciduria	Ewing's sarcoma Myxoid liposarcoma Clear cell sarcoma of soft tissue Extraskeletal myxoid chondrosarcoma
GWAS		Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)	Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252)
Interacting Genes		7 interacting genes: APP ARL6IP5 EWSR1 LDLRAD1 LMNA PRKCA RNF5	161 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C11orf16 C19orf57 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		6505	2130
HPRD ID		00597	00592
Ensembl ID		ENSG00000106688	ENSG00000182944
Uniprot IDs		P43005	Q01844
PDB IDs			2CPE
Enriched GO Terms of Interacting Partners?
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