FBXL12 and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (pull down)

		FBXL12	ECSIT
Description		F-box and leucine rich repeat protein 12	ECSIT signaling integrator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Cell Cycle	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Pursuit maintenance gain ( 29064472)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		22 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MARCHF2 MAST1 PSEN1 PSEN2 PSME3 RNF32 SHFL SMAD1 TGFBR1 UBE2D3 ZNF44 ZNF562 ZNF823	50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		54850	51295
HPRD ID		12363	12225
Ensembl ID		ENSG00000127452	ENSG00000130159
Uniprot IDs		Q9NXK8	Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?
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