FBXL12 and SHFL

		FBXL12	SHFL
Description		F-box and leucine rich repeat protein 12	shiftless antiviral inhibitor of ribosomal frameshifting
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Viral Replication Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Ribosome Binding Sequence-specific MRNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Cell Cycle	Regulation Of Translational Termination Response To Type I Interferon Response To Interferon-gamma Response To Type III Interferon Response To Interferon-beta Negative Regulation Of Viral Genome Replication Defense Response To Virus Viral Translational Frameshifting Negative Regulation Of Translational Frameshifting
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Pursuit maintenance gain ( 29064472)
Interacting Genes		22 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MARCHF2 MAST1 PSEN1 PSEN2 PSME3 RNF32 SHFL SMAD1 TGFBR1 UBE2D3 ZNF44 ZNF562 ZNF823	34 interacting genes: ADAMTSL4 CADPS CCDC136 DRICH1 DTNBP1 ECSIT FBXL12 IKZF1 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 LZTS2 MAGEA1 MDFI MEOX2 MID2 MTUS2 NOTCH2NLA PDE4DIP SPRY2 SSX2IP TCF4 TERF1 TNS2 TRAF1
Entrez ID		54850	55337
HPRD ID		12363	07747
Ensembl ID		ENSG00000127452	ENSG00000130813
Uniprot IDs		Q9NXK8	Q9NUL5
PDB IDs
Enriched GO Terms of Interacting Partners?
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