ECSIT and STAMBPL1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		ECSIT	STAMBPL1
Description		ECSIT signaling integrator	STAM binding protein like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Endosome Cytosol Membrane
	Molecular Function	Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding Lys63-specific Deubiquitinase Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Protein Deubiquitination Protein K63-linked Deubiquitination
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Metalloprotease DUBs
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59	20 interacting genes: A2M CDC37 CEP72 ECSIT GNPTAB GOLGA2 IKZF3 INCA1 LAX1 MAGEA6 MAST1 PNMA1 PSEN1 RAB2A RNF32 SMAD2 SMAD7 TCF4 TRIM27 TRIP13
Entrez ID		51295	57559
HPRD ID		12225	16486
Ensembl ID		ENSG00000130159	ENSG00000138134
Uniprot IDs		Q9BQ95	Q96FJ0
PDB IDs			2ZNR 2ZNV
Enriched GO Terms of Interacting Partners?
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