ECSIT and PI4K2A

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		ECSIT	PI4K2A
Description		ECSIT signaling integrator	phosphatidylinositol 4-kinase type 2 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Mitochondrion Lysosomal Membrane Endosome Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Cell Junction Dendrite Synaptic Vesicle Membrane BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Host Cell Presynaptic Membrane Membrane Raft
	Molecular Function	Protein Binding	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Basophil Degranulation Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphorylation
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59	6 interacting genes: APP CD63 ECSIT HRAS NOS3 RAD23A
Entrez ID		51295	55361
HPRD ID		12225	11431
Ensembl ID		ENSG00000130159	ENSG00000155252
Uniprot IDs		Q9BQ95	Q9BTU6
PDB IDs			4HND 4HNE 4PLA 4YC4 5EUT 5I0N
Enriched GO Terms of Interacting Partners?
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