TP53 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
UBE2K	ubiquitin conjugating enzyme E2 K	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
UBE2L3	ubiquitin conjugating enzyme E2 L3	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
WWOX	WW domain containing oxidoreductase	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
YBX1	Y-box binding protein 1	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Noncanonical activation of NOTCH3
ACKR3	atypical chemokine receptor 3	Chemokine receptors bind chemokines G alpha (i) signalling events
ARID1A	AT-rich interaction domain 1A	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
ATXN3	ataxin 3	Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
BAK1	BCL2 antagonist/killer 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria
CDC14A	cell division cycle 14A	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase MAPK6/MAPK4 signaling
CENPX	centromere protein X	Deposition of new CENPA-containing nucleosomes at the centromere Fanconi Anemia Pathway
COP1	COP1 E3 ubiquitin ligase	Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
DHCR24	24-dehydrocholesterol reductase	Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol		Desmosterolosis
DTL	denticleless E3 ubiquitin protein ligase homolog	Recognition of DNA damage by PCNA-containing replication complex Neddylation
EFEMP2	EGF containing fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
EGLN3	egl-9 family hypoxia inducible factor 3	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Ascorbic acid Roxadustat
EIF2AK2	eukaryotic translation initiation factor 2 alpha kinase 2	ISG15 antiviral mechanism Inhibition of PKR	Fostamatinib
ELL3	elongation factor for RNA polymerase II 3	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
FBXO11	F-box protein 11	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GADD45A	growth arrest and DNA damage inducible alpha	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
GSTM4	glutathione S-transferase mu 4	Glutathione conjugation Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	Glutathione Glutathione sulfonic acid S-octylglutathione Glutathione disulfide gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 1-Hydroxy-2-S-glutathionyl-3-para-nitrophenoxy-propane S-Hexylglutathione

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