TP53 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
HEY1	hes related family bHLH transcription factor with YRPW motif 1	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
HINFP	histone H4 transcription factor
HIPK1	homeodomain interacting protein kinase 1	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Regulation of TP53 Activity through Phosphorylation
HMGA2	high mobility group AT-hook 2	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
HMGB2	high mobility group box 2	Apoptosis induced DNA fragmentation
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U like 1	mRNA Splicing - Major Pathway
HSPA1A	heat shock protein family A (Hsp70) member 1A	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Neutrophil degranulation
HSPA9	heat shock protein family A (Hsp70) member 9	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
IFI16	interferon gamma inducible protein 16	STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
ING1	inhibitor of growth family member 1
ING4	inhibitor of growth family member 4	HATs acetylate histones
ING5	inhibitor of growth family member 5	HATs acetylate histones Regulation of TP53 Activity through Acetylation
IRF7	interferon regulatory factor 7	DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
ITPK1	inositol-tetrakisphosphate 1-kinase	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
KAT6A	lysine acetyltransferase 6A	HATs acetylate histones Regulation of TP53 Activity through Acetylation
KAT7	lysine acetyltransferase 7	HATs acetylate histones
KAT8	lysine acetyltransferase 8	HATs acetylate histones
KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
KDM4D	lysine demethylase 4D	HDMs demethylate histones

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