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EPHA2 |
EPH receptor A2 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
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- Dasatinib
- Phosphoaminophosphonic Acid-Adenylate Ester
- Regorafenib
- Fostamatinib
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EPHA3 |
EPH receptor A3 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
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GPS2 |
G protein pathway suppressor 2 |
- PPARA activates gene expression
- HDACs deacetylate histones
- Loss of MECP2 binding ability to the NCoR/SMRT complex
- Regulation of MECP2 expression and activity
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- HCMV Early Events
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HEY1 |
hes related family bHLH transcription factor with YRPW motif 1 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- RUNX2 regulates osteoblast differentiation
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
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HIPK2 |
homeodomain interacting protein kinase 2 |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- SUMOylation of transcription cofactors
- Physiological factors
- Regulation of TP53 Activity through Phosphorylation
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of MECP2 expression and activity
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KPNA2 |
karyopherin subunit alpha 2 |
- CaMK IV-mediated phosphorylation of CREB
- ISG15 antiviral mechanism
- NS1 Mediated Effects on Host Pathways
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
- Sensing of DNA Double Strand Breaks
- Estrogen-dependent gene expression
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MDC1 |
mediator of DNA damage checkpoint 1 |
- SUMOylation of DNA damage response and repair proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- TP53 Regulates Transcription of DNA Repair Genes
- G2/M DNA damage checkpoint
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MEN1 |
menin 1 |
- Formation of the beta-catenin:TCF transactivating complex
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Deactivation of the beta-catenin transactivating complex
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- RHO GTPases activate IQGAPs
- Post-translational protein phosphorylation
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- Carcinoid
- Adrenal carcinoma
- Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
- Malignant islet cell carcinoma
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NCOA3 |
nuclear receptor coactivator 3 |
- PPARA activates gene expression
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- MAPK6/MAPK4 signaling
- Estrogen-dependent gene expression
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NPM1 |
nucleophosmin 1 |
- Nuclear import of Rev protein
- Nuclear import of Rev protein
- SUMOylation of transcription cofactors
- Deposition of new CENPA-containing nucleosomes at the centromere
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
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SIRT1 |
sirtuin 1 |
- Regulation of HSF1-mediated heat shock response
- Circadian Clock
- SIRT1 negatively regulates rRNA expression
- SIRT1 negatively regulates rRNA expression
- Regulation of FOXO transcriptional activity by acetylation
- Regulation of FOXO transcriptional activity by acetylation
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- Resveratrol
- Selisistat
- Cambinol
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STX5 |
syntaxin 5 |
- COPII-mediated vesicle transport
- Cargo concentration in the ER
- COPI-mediated anterograde transport
- Intra-Golgi traffic
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
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ASH2L |
ASH2 like, histone lysine methyltransferase complex subunit |
- Formation of the beta-catenin:TCF transactivating complex
- PKMTs methylate histone lysines
- Deactivation of the beta-catenin transactivating complex
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
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BCL2L1 |
BCL2 like 1 |
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- RAS processing
- STAT5 activation downstream of FLT3 ITD mutants
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- 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
- Isosorbide
- Gossypol
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BMP1 |
bone morphogenetic protein 1 |
- Degradation of the extracellular matrix
- Degradation of the extracellular matrix
- Collagen biosynthesis and modifying enzymes
- Anchoring fibril formation
- Crosslinking of collagen fibrils
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BRF1 |
BRF1 RNA polymerase III transcription initiation factor subunit |
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- RNA Polymerase III Transcription Initiation From Type 1 Promoter
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
- RNA Polymerase III Transcription Initiation From Type 2 Promoter
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CDC34 |
cell division cycle 34, ubiqiutin conjugating enzyme |
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- CLEC7A (Dectin-1) signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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CDKN2B |
cyclin dependent kinase inhibitor 2B |
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Cyclin D associated events in G1
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- Malignant pleural mesothelioma
- Osteosarcoma
- Type II diabetes mellitus
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DDX5 |
DEAD-box helicase 5 |
- SUMOylation of transcription cofactors
- mRNA Splicing - Major Pathway
- Estrogen-dependent gene expression
- Replication of the SARS-CoV-1 genome
- Replication of the SARS-CoV-2 genome
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DNAJB1 |
DnaJ heat shock protein family (Hsp40) member B1 |
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Attenuation phase
- HSF1-dependent transactivation
- MAPK6/MAPK4 signaling
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