TP53 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
MAPK8	mitogen-activated protein kinase 8	Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation DSCAM interactions JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping	Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
MAPK9	mitogen-activated protein kinase 9	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
MAPKAPK5	MAPK activated protein kinase 5	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	Fostamatinib
MDC1	mediator of DNA damage checkpoint 1	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
MDH1	malate dehydrogenase 1	Gluconeogenesis	NADH Nicotinamide adenine dinucleotide phosphate Artenimol
MDM4	MDM4 regulator of p53	Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
MED1	mediator complex subunit 1	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression	Becocalcidiol
MED17	mediator complex subunit 17	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
MED21	mediator complex subunit 21	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
MIF	macrophage migration inhibitory factor	Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
MKRN2	makorin ring finger protein 2
MNAT1	MNAT1 component of CDK activating kinase	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
MNDA	myeloid cell nuclear differentiation antigen	Neutrophil degranulation
MPHOSPH6	M-phase phosphoprotein 6	Major pathway of rRNA processing in the nucleolus and cytosol
MSL2	MSL complex subunit 2	HATs acetylate histones
MTA1	metastasis associated 1	HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
MTA2	metastasis associated 1 family member 2	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
MUC1	mucin 1, cell surface associated	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	TG4010
MUL1	mitochondrial E3 ubiquitin protein ligase 1	Ub-specific processing proteases
MVP	major vault protein	Neutrophil degranulation

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