EGFR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SNX9	sorting nexin 9	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
SOCS5	suppressor of cytokine signaling 5	Interleukin-4 and Interleukin-13 signaling Neddylation
SPARCL1	SPARC like 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
TPI1	triosephosphate isomerase 1	Glycolysis Gluconeogenesis	Zinc N-Hydroxy-4-Phosphono-Butanamide 2-Phosphoglycolic Acid Phosphoglycolohydroxamic Acid 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid 5-fluorotryptophan 2-Carboxyethylphosphonic Acid tert-butanol Dihydroxyacetone phosphate 1,4-Dithiothreitol 3-phospho-D-glyceric acid 3-(BUTYLSULPHONYL)-PROPANOIC ACID Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
TPM1	tropomyosin 1	Striated Muscle Contraction Smooth Muscle Contraction	Artenimol Phenethyl Isothiocyanate	Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
TXK	TXK tyrosine kinase	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Fostamatinib Zanubrutinib
ZAP70	zeta chain of T cell receptor associated protein kinase 70	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Staurosporine Fostamatinib	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
ACTA1	actin alpha 1, skeletal muscle	Striated Muscle Contraction	Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B	Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
ALCAM	activated leukocyte cell adhesion molecule	L1CAM interactions
AOPEP	aminopeptidase O (putative)	Metabolism of Angiotensinogen to Angiotensins
APBA3	amyloid beta precursor protein binding family A member 3	Neurexins and neuroligins
APBB1	amyloid beta precursor protein binding family B member 1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
APPL1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Caspase activation via Dependence Receptors in the absence of ligand
ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Purine ribonucleoside monophosphate biosynthesis	Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid	AICA-ribosiduria; ATIC deficiency
AXL	AXL receptor tyrosine kinase	VEGFA-VEGFR2 Pathway	Fostamatinib Gilteritinib
CAMLG	calcium modulating ligand	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Cyclosporine
CAV2	caveolin 2	Extra-nuclear estrogen signaling
CBLB	Cbl proto-oncogene B	Antigen processing: Ubiquitination & Proteasome degradation
CSRP1	cysteine and glycine rich protein 1	MTF1 activates gene expression	Artenimol
DOK4	docking protein 4	RET signaling

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