EGFR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
FKBP4	FKBP prolyl isomerase 4	HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
GRB2	growth factor receptor bound protein 2	Interleukin-15 signaling Interleukin-15 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants	Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
GRB7	growth factor receptor bound protein 7	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling
ICAM1	intercellular adhesion molecule 1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Natalizumab Hyaluronic acid Nafamostat	Allograft rejection
JUP	junction plakoglobin	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
MAP3K14	mitogen-activated protein kinase kinase kinase 14	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
NEDD4	NEDD4 E3 ubiquitin protein ligase	ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
PRKCE	protein kinase C epsilon	Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events	Tamoxifen KAI-1455 Bryostatin 1 Fostamatinib
SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling
STAT2	signal transducer and activator of transcription 2	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
TJP1	tight junction protein 1	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
TNC	tenascin C	Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
XRCC6	X-ray repair cross complementing 6	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
AGTR1	angiotensin II receptor type 1	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Renal tubular dysgenesis
ALDOA	aldolase, fructose-bisphosphate A	Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
ARF4	ADP ribosylation factor 4	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Guanosine-5'-Diphosphate
ARHGEF12	Rho guanine nucleotide exchange factor 12	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
ATP1B1	ATPase Na+/K+ transporting subunit beta 1	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
FES	FES proto-oncogene, tyrosine kinase	Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Fostamatinib
GJB1	gap junction protein beta 1	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy

Search Results for: EGFR