EGFR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SOCS6	suppressor of cytokine signaling 6	Regulation of KIT signaling Neddylation Negative regulation of FLT3
SUPT6H	SPT6 homolog, histone chaperone and transcription elongation factor	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
ADRM1	adhesion regulating molecule 1	UCH proteinases Ub-specific processing proteases
AIP	aryl hydrocarbon receptor interacting protein	Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
AMH	anti-Mullerian hormone	Signaling by BMP Transcriptional regulation of testis differentiation		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
ATP5F1C	ATP synthase F1 subunit gamma	Formation of ATP by chemiosmotic coupling Cristae formation	Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
BLK	BLK proto-oncogene, Src family tyrosine kinase	RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Fostamatinib Zanubrutinib	Maturity onset diabetes of the young (MODY)
BMX	BMX non-receptor tyrosine kinase	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane	Fostamatinib Zanubrutinib
CAV3	caveolin 3	Smooth Muscle Contraction Smooth Muscle Contraction		Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Limb-girdle muscular dystrophy (LGMD)
CDH5	cadherin 5	Adherens junctions interactions VEGFR2 mediated vascular permeability	Lenalidomide FX06
CTTN	cortactin	RHO GTPases activate PAKs Clathrin-mediated endocytosis
DEGS1	delta 4-desaturase, sphingolipid 1	Sphingolipid de novo biosynthesis Neutrophil degranulation
DOK2	docking protein 2	Tie2 Signaling RET signaling
FANCC	FA complementation group C	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes		Fanconi anemia
FRAT2	FRAT regulator of WNT signaling pathway 2	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
FRK	fyn related Src family tyrosine kinase	Neutrophil degranulation Regulation of PTEN stability and activity	Dasatinib Regorafenib Fostamatinib Zanubrutinib
GABARAPL2	GABA type A receptor associated protein like 2	Macroautophagy TBC/RABGAPs
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	Glycolysis Gluconeogenesis	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
GGA1	golgi associated, gamma adaptin ear containing, ARF binding protein 1	TBC/RABGAPs Amyloid fiber formation
HPN	hepsin	MET Receptor Activation Signaling by MST1	Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine

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