EGFR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ITSN2	intersectin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
KRT17	keratin 17	Keratinization Formation of the cornified envelope		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT18	keratin 18	Keratinization Formation of the cornified envelope
KRT7	keratin 7	Keratinization Formation of the cornified envelope	Primaquine Verpasep caltespen
KRT8	keratin 8	Keratinization Formation of the cornified envelope	Tenecteplase Lanoteplase Copper
LAT	linker for activation of T cells	GPVI-mediated activation cascade Generation of second messenger molecules
LRP1	LDL receptor related protein 1	Scavenging of heme from plasma Retinoid metabolism and transport	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
MT-CO2	cytochrome c oxidase subunit II	TP53 Regulates Metabolic Genes Respiratory electron transport	Cholic Acid N-Formylmethionine Talmapimod
NF2	neurofibromin 2	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs		Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
PDK3	pyruvate dehydrogenase kinase 3	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Radicicol Dihydrolipoic Acid
PITPNA	phosphatidylinositol transfer protein alpha	Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent 1A	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
PTGDS	prostaglandin D2 synthase	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation	Vitamin A
PTPN18	protein tyrosine phosphatase non-receptor type 18	Downregulation of ERBB2 signaling Interleukin-37 signaling
PTPN2	protein tyrosine phosphatase non-receptor type 2	Negative regulation of MET activity Interleukin-37 signaling		Type I diabetes mellitus
PTPN22	protein tyrosine phosphatase non-receptor type 22	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse		Type I diabetes mellitus
PTPN7	protein tyrosine phosphatase non-receptor type 7	Negative regulation of MAPK pathway Interleukin-37 signaling
S100A7	S100 calcium binding protein A7	Neutrophil degranulation Metal sequestration by antimicrobial proteins	Ibuprofen Zinc 8-anilinonaphthalene-1-sulfonic acid Dexibuprofen Zinc acetate Zinc chloride Zinc sulfate, unspecified form
SH2B2	SH2B adaptor protein 2	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
SHB	SH2 domain containing adaptor protein B	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway

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