AR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CDC25B	cell division cycle 25B	Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	L-cysteic acid
GSN	gelsolin	Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Amyloid fiber formation	Zinc Latrunculin A Copper Zinc acetate	Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
IDE	insulin degrading enzyme	Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import	Insulin pork Bacitracin
INPPL1	inositol polyphosphate phosphatase like 1	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling
KLK2	kallikrein related peptidase 2	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
MYLIP	myosin regulatory light chain interacting protein	VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
POU5F1	POU class 5 homeobox 1	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
RACK1	receptor for activated C kinase 1	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production	Copper
RANBP9	RAN binding protein 9	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
SMAD1	SMAD family member 1	Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development
SOCS6	suppressor of cytokine signaling 6	Regulation of KIT signaling Neddylation Negative regulation of FLT3
TRIM24	tripartite motif containing 24	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
TXNDC5	thioredoxin domain containing 5	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
BLK	BLK proto-oncogene, Src family tyrosine kinase	RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Fostamatinib Zanubrutinib	Maturity onset diabetes of the young (MODY)
COX5B	cytochrome c oxidase subunit 5B	TP53 Regulates Metabolic Genes Respiratory electron transport	Cholic Acid N-Formylmethionine
DDC	dopa decarboxylase	Catecholamine biosynthesis Serotonin and melatonin biosynthesis	Pyridoxal phosphate Carbidopa Methyldopa Benserazide
FOXG1	forkhead box G1	Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes		Rett syndrome
GAK	cyclin G associated kinase	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Fostamatinib
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	Glycolysis Gluconeogenesis	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
IARS1	isoleucyl-tRNA synthetase 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Isoleucine

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