Search Results for: AR

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
CDC25B cell division cycle 25B
  • Cyclin A/B1/B2 associated events during G2/M transition
  • Cyclin A:Cdk2-associated events at S phase entry
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • L-cysteic acid
GSN gelsolin
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Neutrophil degranulation
  • Amyloid fiber formation
  • Zinc
  • Latrunculin A
  • Copper
  • Zinc acetate
  • Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome
  • Familial amyloidosis
IDE insulin degrading enzyme
  • Ub-specific processing proteases
  • Peroxisomal protein import
  • Peroxisomal protein import
  • Insulin pork
  • Bacitracin
INPPL1 inositol polyphosphate phosphatase like 1
  • Synthesis of PIPs at the plasma membrane
  • Synthesis of IP3 and IP4 in the cytosol
  • Interleukin receptor SHC signaling
KLK2 kallikrein related peptidase 2
  • Activation of Matrix Metalloproteinases
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
MYLIP myosin regulatory light chain interacting protein
  • VLDLR internalisation and degradation
  • NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
  • Antigen processing: Ubiquitination & Proteasome degradation
POU5F1 POU class 5 homeobox 1
  • POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
  • POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
  • Transcriptional regulation of pluripotent stem cells
RACK1 receptor for activated C kinase 1
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
  • TNFR1-mediated ceramide production
  • Copper
RANBP9 RAN binding protein 9
  • L1CAM interactions
  • RAF/MAP kinase cascade
  • MET activates RAS signaling
SMAD1 SMAD family member 1
  • Signaling by BMP
  • Ub-specific processing proteases
  • RUNX2 regulates bone development
SOCS6 suppressor of cytokine signaling 6
  • Regulation of KIT signaling
  • Neddylation
  • Negative regulation of FLT3
TRIM24 tripartite motif containing 24
  • Signaling by cytosolic FGFR1 fusion mutants
  • Signaling by FGFR1 in disease
  • Signaling by BRAF and RAF fusions
TXNDC5 thioredoxin domain containing 5
  • Lysosome Vesicle Biogenesis
  • Golgi Associated Vesicle Biogenesis
  • Neutrophil degranulation
BLK BLK proto-oncogene, Src family tyrosine kinase
  • RUNX1 regulates transcription of genes involved in BCR signaling
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
  • Fostamatinib
  • Zanubrutinib
  • Maturity onset diabetes of the young (MODY)
COX5B cytochrome c oxidase subunit 5B
  • TP53 Regulates Metabolic Genes
  • Respiratory electron transport
  • Cholic Acid
  • N-Formylmethionine
DDC dopa decarboxylase
  • Catecholamine biosynthesis
  • Serotonin and melatonin biosynthesis
  • Pyridoxal phosphate
  • Carbidopa
  • Methyldopa
  • Benserazide
FOXG1 forkhead box G1
  • Regulation of MECP2 expression and activity
  • FOXO-mediated transcription of cell cycle genes
  • Rett syndrome
GAK cyclin G associated kinase
  • Golgi Associated Vesicle Biogenesis
  • Clathrin-mediated endocytosis
  • Fostamatinib
GAPDH glyceraldehyde-3-phosphate dehydrogenase
  • Glycolysis
  • Gluconeogenesis
  • NADH
  • Adenosine-5-Diphosphoribose
  • Thionicotinamide-Adenine-Dinucleotide
  • 4-(2-Aminoethyl)Benzenesulfonyl Fluoride
  • Xanthinol
  • Copper
  • Artenimol
IARS1 isoleucyl-tRNA synthetase 1
  • Selenoamino acid metabolism
  • Cytosolic tRNA aminoacylation
  • Isoleucine

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