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NCOA6 |
nuclear receptor coactivator 6 |
- RORA activates gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- Regulation of lipid metabolism by PPARalpha
- Circadian Clock
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
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CALR |
calreticulin |
- ER-Phagosome pathway
- Assembly of Viral Components at the Budding Site
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- Scavenging by Class F Receptors
- Scavenging by Class F Receptors
- ATF6 (ATF6-alpha) activates chaperone genes
- Calnexin/calreticulin cycle
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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- Antihemophilic factor, human recombinant
- Tenecteplase
- Melatonin
- Lanoteplase
- Copper
- Calcium citrate
- Calcium Phosphate
- Lonoctocog alfa
- Moroctocog alfa
- Calcium phosphate dihydrate
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CDC25A |
cell division cycle 25A |
- Transcription of E2F targets under negative control by DREAM complex
- Polo-like kinase mediated events
- Activation of ATR in response to replication stress
- Ub-specific processing proteases
- Cyclin E associated events during G1/S transition
- Cyclin A/B1/B2 associated events during G2/M transition
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Cyclin A:Cdk2-associated events at S phase entry
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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CUL4B |
cullin 4B |
- Recognition of DNA damage by PCNA-containing replication complex
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Neddylation
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- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
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DCC |
DCC netrin 1 receptor |
- Netrin-1 signaling
- Netrin-1 signaling
- DSCAM interactions
- DCC mediated attractive signaling
- DCC mediated attractive signaling
- Netrin mediated repulsion signals
- Caspase activation via Dependence Receptors in the absence of ligand
- Role of second messengers in netrin-1 signaling
- Regulation of commissural axon pathfinding by SLIT and ROBO
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- Colorectal cancer
- Gastric cancer
- Cancer of the anal canal
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PIAS1 |
protein inhibitor of activated STAT 1 |
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- Formation of Incision Complex in GG-NER
- Regulation of IFNG signaling
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RAN |
RAN, member RAS oncogene family |
- Rev-mediated nuclear export of HIV RNA
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- NEP/NS2 Interacts with the Cellular Export Machinery
- Nuclear import of Rev protein
- MicroRNA (miRNA) biogenesis
- Transcriptional regulation by small RNAs
- tRNA processing in the nucleus
- Postmitotic nuclear pore complex (NPC) reformation
- Postmitotic nuclear pore complex (NPC) reformation
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TAF1 |
TATA-box binding protein associated factor 1 |
- HIV Transcription Initiation
- RNA Polymerase II HIV Promoter Escape
- Transcription of the HIV genome
- RNA Polymerase II Pre-transcription Events
- Regulation of TP53 Activity through Phosphorylation
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
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CASP1 |
caspase 1 |
- NOD1/2 Signaling Pathway
- Interleukin-1 processing
- TP53 Regulates Transcription of Caspase Activators and Caspases
- The NLRP3 inflammasome
- The AIM2 inflammasome
- The IPAF inflammasome
- Interleukin-37 signaling
- Purinergic signaling in leishmaniasis infection
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- Acetylsalicylic acid
- Minocycline
- Pralnacasan
- LAX-101
- Emricasan
- VX-765
- 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
- Z-Val-Ala-Asp fluoromethyl ketone
- 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
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CAV1 |
caveolin 1 |
- Triglyceride catabolism
- eNOS activation
- NOSTRIN mediated eNOS trafficking
- Basigin interactions
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- VEGFR2 mediated vascular permeability
- Extra-nuclear estrogen signaling
- FOXO-mediated transcription of cell cycle genes
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- Congenital generalized lipodystrophy (CGL)
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CDK6 |
cyclin dependent kinase 6 |
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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- Alvocidib
- (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol
- Fisetin
- Palbociclib
- Ribociclib
- Abemaciclib
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EED |
embryonic ectoderm development |
- PRC2 methylates histones and DNA
- Oxidative Stress Induced Senescence
- PKMTs methylate histone lysines
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Transcriptional Regulation by E2F6
- HCMV Early Events
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EZH2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
- PRC2 methylates histones and DNA
- Oxidative Stress Induced Senescence
- PKMTs methylate histone lysines
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Transcriptional Regulation by E2F6
- HCMV Early Events
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GRAP2 |
GRB2 related adaptor protein 2 |
- Signaling by SCF-KIT
- Generation of second messenger molecules
- DAP12 signaling
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- CD28 co-stimulation
- FLT3 Signaling
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HDAC4 |
histone deacetylase 4 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- RUNX2 regulates chondrocyte maturation
- RUNX3 regulates p14-ARF
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- Zinc
- Belinostat
- Romidepsin
- Panobinostat
- N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide
- 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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- Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
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KDM1A |
lysine demethylase 1A |
- HDACs deacetylate histones
- HDMs demethylate histones
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- Potential therapeutics for SARS
- Factors involved in megakaryocyte development and platelet production
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VHL |
von Hippel-Lindau tumor suppressor |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- SUMOylation of ubiquitinylation proteins
- Neddylation
- Replication of the SARS-CoV-1 genome
- Replication of the SARS-CoV-2 genome
- RHOBTB3 ATPase cycle
- Antigen processing: Ubiquitination & Proteasome degradation
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- Renal cell carcinoma
- von Hippel-Lindau syndrome
- Congenital polycythemia; Familial erythrocytosis (ECYT)
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HCK |
HCK proto-oncogene, Src family tyrosine kinase |
- Nef and signal transduction
- FCGR activation
- Regulation of signaling by CBL
- Regulation of signaling by CBL
- FCGR3A-mediated IL10 synthesis
- FCGR3A-mediated phagocytosis
- FLT3 signaling through SRC family kinases
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- 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
- Phosphonotyrosine
- Quercetin
- Bosutinib
- Fostamatinib
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HMGB1 |
high mobility group box 1 |
- Apoptosis induced DNA fragmentation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Regulation of TLR by endogenous ligand
- Neutrophil degranulation
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- TRAF6 mediated NF-kB activation
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- Chloroquine
- Ethyl pyruvate
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NR3C1 |
nuclear receptor subfamily 3 group C member 1 |
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Circadian Clock
- SUMOylation of intracellular receptors
- PTK6 Expression
- Regulation of RUNX2 expression and activity
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Potential therapeutics for SARS
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- Flunisolide
- Diflorasone
- Alclometasone
- Medrysone
- Amcinonide
- Fluorometholone
- Megestrol acetate
- Levonorgestrel
- Beclomethasone dipropionate
- Progesterone
- Spironolactone
- Betamethasone
- Desoximetasone
- Fluticasone propionate
- Fluocinolone acetonide
- Ulobetasol
- Triamcinolone
- Prednisone
- Flumethasone
- Fludrocortisone
- Norethisterone
- Hydrocortisone
- Mometasone
- Hydrocortamate
- Mifepristone
- Clocortolone
- Flurandrenolide
- Prednisolone
- Loteprednol etabonate
- Rimexolone
- Methylprednisolone
- Clobetasol propionate
- Fluocinonide
- Prednicarbate
- Fluoxymesterone
- Budesonide
- Dexamethasone
- Desonide
- Cortisone acetate
- Paramethasone
- Drospirenone
- Ciclesonide
- Hexane-1,6-Diol
- Aldosterone
- ORG-34517
- Difluprednate
- Ulipristal
- Fluticasone furoate
- Tixocortol
- Difluocortolone
- Gestrinone
- Deflazacort
- Onapristone
- Cortivazol
- Clobetasone
- Fluticasone
- Mometasone furoate
- Hydrocortisone aceponate
- Hydrocortisone acetate
- Hydrocortisone butyrate
- Hydrocortisone cypionate
- Hydrocortisone phosphate
- Hydrocortisone probutate
- Hydrocortisone valerate
- Segesterone acetate
- Prednisolone phosphate
- Dexamethasone acetate
- Betamethasone phosphate
- Prednisolone acetate
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- 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
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