AR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
IFI16	interferon gamma inducible protein 16	STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
KIF1A	kinesin family member 1A	COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Phosphoaminophosphonic Acid-Adenylate Ester
NR2C1	nuclear receptor subfamily 2 group C member 1	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
NR3C2	nuclear receptor subfamily 3 group C member 2	HSP90 chaperone cycle for steroid hormone receptors (SHR) SUMOylation of intracellular receptors	Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Testosterone undecanoate Stanolone acetate	Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Hypertension exacerbated in pregnancy
PELP1	proline, glutamate and leucine rich protein 1	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
POU2F2	POU class 2 homeobox 2	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
PRPF6	pre-mRNA processing factor 6	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
RAC3	Rac family small GTPase 3	Rho GTPase cycle PCP/CE pathway
RCHY1	ring finger and CHY zinc finger domain containing 1	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
REPS2	RALBP1 associated Eps domain containing 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
RNASEL	ribonuclease L	OAS antiviral response Interferon alpha/beta signaling
RNF4	ring finger protein 4	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
SFPQ	splicing factor proline and glutamine rich	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis	Copper Artenimol
SHB	SH2 domain containing adaptor protein B	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Phenethyl Isothiocyanate
SREBF1	sterol regulatory element binding transcription factor 1	RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
SRY	sex determining region Y	Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
TADA3	transcriptional adaptor 3	HATs acetylate histones Ub-specific processing proteases

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