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POU2F1 |
POU class 2 homeobox 1 |
- Interleukin-4 and Interleukin-13 signaling
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- Estrogen-dependent gene expression
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SMARCA4 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
- Interleukin-7 signaling
- Formation of the beta-catenin:TCF transactivating complex
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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SP1 |
Sp1 transcription factor |
- PPARA activates gene expression
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Activation of gene expression by SREBF (SREBP)
- Oncogene Induced Senescence
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- Estrogen-dependent gene expression
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STUB1 |
STIP1 homology and U-box containing protein 1 |
- Downregulation of TGF-beta receptor signaling
- RIPK1-mediated regulated necrosis
- Regulation of necroptotic cell death
- Downregulation of ERBB2 signaling
- Regulation of RUNX2 expression and activity
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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CASP7 |
caspase 7 |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Apoptotic cleavage of cellular proteins
- SMAC, XIAP-regulated apoptotic response
- Caspase-mediated cleavage of cytoskeletal proteins
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- Fica
- Emricasan
- Incadronic acid
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DAXX |
death domain associated protein |
- SUMOylation of transcription cofactors
- Regulation of TP53 Degradation
- HCMV Early Events
- Inhibition of DNA recombination at telomere
- Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
- Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
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DDB2 |
damage specific DNA binding protein 2 |
- Ub-specific processing proteases
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Dual Incision in GG-NER
- TP53 Regulates Transcription of DNA Repair Genes
- Neddylation
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- Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
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IL6ST |
interleukin 6 cytokine family signal transducer |
- Interleukin-6 signaling
- Interleukin-6 signaling
- IL-6-type cytokine receptor ligand interactions
- Interleukin-35 Signalling
- Interleukin-27 signaling
- Interleukin-27 signaling
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KIFAP3 |
kinesin associated protein 3 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- MHC class II antigen presentation
- Intraflagellar transport
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
- Kinesins
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NCOA3 |
nuclear receptor coactivator 3 |
- PPARA activates gene expression
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- MAPK6/MAPK4 signaling
- Estrogen-dependent gene expression
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PIAS3 |
protein inhibitor of activated STAT 3 |
- SUMOylation of transcription factors
- SUMOylation of transcription cofactors
- SUMOylation of intracellular receptors
- SUMOylation of DNA replication proteins
- SUMOylation of immune response proteins
- Formation of Incision Complex in GG-NER
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PXN |
paxillin |
- GAB1 signalosome
- VEGFA-VEGFR2 Pathway
- Smooth Muscle Contraction
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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RAD9A |
RAD9 checkpoint clamp component A |
- Activation of ATR in response to replication stress
- HDR through Single Strand Annealing (SSA)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
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RASA1 |
RAS p21 protein activator 1 |
- Downstream signal transduction
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- VEGFR2 mediated cell proliferation
- Regulation of RAS by GAPs
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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- RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
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SIRT1 |
sirtuin 1 |
- Regulation of HSF1-mediated heat shock response
- Circadian Clock
- SIRT1 negatively regulates rRNA expression
- SIRT1 negatively regulates rRNA expression
- Regulation of FOXO transcriptional activity by acetylation
- Regulation of FOXO transcriptional activity by acetylation
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- Resveratrol
- Selisistat
- Cambinol
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YWHAQ |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Regulation of localization of FOXO transcription factors
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AHR |
aryl hydrocarbon receptor |
- PPARA activates gene expression
- Phase I - Functionalization of compounds
- Endogenous sterols
- Xenobiotics
- Aryl hydrocarbon receptor signalling
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- Omeprazole
- Mexiletine
- Nimodipine
- Flutamide
- Atorvastatin
- Leflunomide
- Ginseng
- Indirubin-3'-monoxime
- Resveratrol
- Quercetin
- beta-Naphthoflavone
- Emodin
- 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine
- Diosmin
- Indigotindisulfonic acid
- Kynurenic Acid
- Epigallocatechin gallate
- Cantharidin
- Indirubin
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FGR |
FGR proto-oncogene, Src family tyrosine kinase |
- FCGR activation
- Platelet sensitization by LDL
- Neutrophil degranulation
- FCGR3A-mediated IL10 synthesis
- FCGR3A-mediated phagocytosis
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- Dasatinib
- Fostamatinib
- Zanubrutinib
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FLNA |
filamin A |
- Platelet degranulation
- GP1b-IX-V activation signalling
- Cell-extracellular matrix interactions
- RHO GTPases activate PAKs
- OAS antiviral response
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- Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
- Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
- Periventricular nodular heterotopia (PVNH)
- FG syndrome (FGS); Opitz-Kaveggia syndrome
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GLI2 |
GLI family zinc finger 2 |
- Degradation of GLI2 by the proteasome
- Hedgehog 'off' state
- Hedgehog 'on' state
- GLI proteins bind promoters of Hh responsive genes to promote transcription
- RUNX2 regulates chondrocyte maturation
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