JOSD1 and USP28

Data Source:
BioGRID (enzymatic study)

		JOSD1	USP28
Description		Josephin domain containing 1	ubiquitin specific peptidase 28
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation	DNA Damage Checkpoint DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Josephin domain DUBs	Ub-specific processing proteases
Drugs
Diseases
GWAS		Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		9929	57646
HPRD ID		08823	15632
Ensembl ID		ENSG00000100221	ENSG00000048028
Uniprot IDs		A0A024R1P5 Q15040	B4E3L3 Q96RU2
PDB IDs			2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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