SETDB1 and USP11

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SETDB1	USP11
Description		SET domain bifurcated histone lysine methyltransferase 1	ubiquitin specific peptidase 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Ras Protein Signal Transduction Negative Regulation Of Gene Expression Response To Vitamin Response To Ethanol Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Deubiquitination Protein Phosphopantetheinylation
Pathways		PKMTs methylate histone lysines	Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		109 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4-16 HDAC1 HDAC2 HMOX2 HSF2BP HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24	21 interacting genes: BMI1 BRCA2 CBX8 CDKN1A DECR2 EIF4B LIMS1 LLGL1 MBD3 MTA2 PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC
Entrez ID		9869	8237
HPRD ID		06828	02081
Ensembl ID		ENSG00000143379	ENSG00000102226
Uniprot IDs		Q15047	B4DGK3 P51784
PDB IDs		3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI	4MEL 5OK6
Enriched GO Terms of Interacting Partners?
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