CKAP5 and USP19

Data Source:
BioGRID (two hybrid)

		CKAP5	USP19
Description		cytoskeleton associated protein 5	ubiquitin specific peptidase 19
Image
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Gamma-tubulin Complex Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end	Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Microtubule Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus End Polymerase	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Hsp90 Protein Binding Lys48-specific Deubiquitinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking	Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Protein K48-linked Deubiquitination Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Ub-specific processing proteases
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: ARHGEF16 AURKA CACNA1A CLASP1 CLK1 NDC80 PTPRN2 SLAIN2 SUMO2 TOP1 USP19	13 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 UBC
Entrez ID		9793	10869
HPRD ID		10830	18278
Ensembl ID		ENSG00000175216	ENSG00000172046
Uniprot IDs		Q14008	O94966
PDB IDs		4QMI 4QMJ	1WH0 4X3G 6K7W 6KHV 6KQV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?